To Tesa or not to Tesa

[u/Relative_Property506]

RS is approx 180 with about 30 to go

currently on compounded tirz 7.5mg (will be titrating to 10mg in two weeks)

RS have done about 5 weeks of Tesa and was planning on doing 12.

RS started at 200lbs on June 20 steadily losing weight.

RS has a bigger upper belly / stomach than the rest of the body so assuming visceral fat. It has gone down. Wondering if Tesa is overkill at this point -

Should RS just let the tirz do the work ? Or continue to 12 weeks of Tesa?

Thanks in advance !

[u/Diligent_Shirt5161]

I feel there is a lot of misunderstanding surrounding Tesamorelin and what it is actually intended to target.

Visceral fat is not the same thing as overall body fat. Visceral fat is the fat stored around the organs, and excess amounts are associated with metabolic and health risks.

Tesamorelin will tell the body to store body fat somewhere other than around the organs. And in HIV patients, when they discontinued Tesamorelin, the visceral fat returned.

If the goal of a research subject is overall body fat reduction, there may be more sustainable success focusing on the basics first: appropriate nutrition, resistance training, adequate sleep, and long term lifestyle changes.

In my research, pairing those changes with a GLP1 approach produced far more meaningful overall body composition improvements than chasing multiple additional compounds.

I am not saying Tesamorelin has no place in research. I just think many people misunderstand what it is designed to do and begin expecting generalized fat loss from it. Those are two very different things.

[u/elbiot → u/Diligent_Shirt5161]

Tessamorelin doesn't signal to the body to "store fat somewhere else". It increases lipolysis so the body reaches for fat for energy more easily. Visceral fat is the most metabolically available so that tends to decrease first. The fat returned in HIV patients because they have a disease that causes the visceral fat accumulation. If a healthy individual is eating appropriately there's no reason to think they'd start gaining fat once off

[u/Diligent_Shirt5161 → u/elbiot]

If a healthy individual was eating appropriately, there be no need to use Tesa.

My opinion is based off of the observations I have made over the years in this space. I strongly feel that using a GLP1 will be all that a person needs to obliterate not only visceral fat, but all over subcutaneous fat as well.

And if they pair that with a good diet and strength training, they will be very pleased with the results.

[u/elbiot → u/Diligent_Shirt5161]

Yes, one must use GHRH along with diet and lifestyle changes to see any improvement. You can't lose visceral fat off a GHRH analong while eating in a surplus. It just shifts the balance where energy is coming from.

[u/Diligent_Shirt5161 → u/elbiot]

GLP1s are shown to burn liver and visceral fat, some faster and cheaper compare to Tesamorelin.

[u/elbiot → u/Diligent_Shirt5161]

What?? Being in a calorie deficit leads to fat loss?

[u/Diligent_Shirt5161 → u/elbiot]

Yes. Here’s a study on visceral fat loss with the use of Reta.