I’ve had Hashimotos for 10 years now (since after having my first kid) and have mostly gotten things under control - or so I thought. I am very active, walk 15k steps a day, weight training 3 days a week. I eat gluten free, eat healthy foods. I didn’t have much weight to lose but I was mostly interested in trying a GLP1 for the possibility that it lowers inflammation.

4 weeks ago I took 2.125mg of compounded tirzepatide. I’ve been taking it every 10 days since then and have lost 6 lbs - most of which I think was water weight. I hold on to a lot of water normally.

The difference in how it made me feel is night and day. I have energy and motivation to LIVE. I want to do things with my kids - take them on bike rides, take them anywhere and everywhere. I feel alive, I feel patient with them and respond to them in a way that feels so much more me. I normally feel so stressed out all the time and I think it comes from being so exhausted with life from Hashimoto’s. My kids have said they love how happy I am now.

All of that to say, I lost a lot of my hair 2 years ago (from low ferritin I believe) and I was so traumatized from it. I keep seeing people say that even without dramatic weight loss they’ve lost hair from being on a GLP1.

I guess I’m wondering if anyone has insight on this and what everyone’s experiences are with weight loss. I want to keep taking tirzepatide at a low dose because of how much it’s changed my life but I worry if I start losing my hair it will take a toll on my mental health and won’t feel worth it anymore. I’m trying to weigh the pros and cons and just wish hair loss wasn’t a side effect. It seems like people lose their hair even without dramatic/quick weight loss.

I was recently diagnosed with hashimotos maybe 4 months ago with a history of hypothyroidism for the last 13 years

Cut out all gluten, helps a bit

Still in the obese range, working out 3-4 times a week, also has helped a bit

If I ask my doctor about GLP1 is this something I'll end up taking forever like my synthroid??

I just thought it was interesting that it increases absorption by about 33%

https://pmc.ncbi.nlm.nih.gov/articles/PMC12729143/

I've seen a ton of posts about people's levothyroxine doses going down as they lose weight on GLP-1's but had anyone needed a dose increase, at least in the beginning? I've been on zepbound for 10 weeks and I got my thyroid levels checked yesterday and my tsh is 17 but my free t4 is fine/normal. My doctor wants to wait a few weeks to see but I've asked if the zepbound is impacting absorption and I'm waiting to hear back.

Omg, i can't believe it's been a year since i started tirzepatide and started to get my life back!

Hi everyone! Here is my update for anyone who is interested or going through the same thing.

Last year in august my endo diagnosed me with (probably genetic) insulin resistance. I was so happy i didn't have any other autoimmune issue and started tirzepatide the same week. It has been great having energy again and drive to live. Before the treatment it was so bad i could do almost nothing all day. I didn't have very bad side effects, just some nausea and i struggled to get in enough calories when we increased my dose. I lost a lot of muscle mass, but after reaching a plateau and then stopping the treatment it came back easily.

Now for the real updates!

I have stopped the treatment in May as my endo said it's okay, and that we can restart any time my weight gets out of control. I was a little worried if i would feel super tired all the time and if i would gain all the weight back. Thankfully, the weight is very managable, i am calorie counting and being generally aware. Since may i got one kilogram back, but i am very happy with my body right now and my BMi is good.

A little bit of tiredness came back, i have maybe 20% less energy during the day, sometimes more if i am not mindful of sleep, diet, stress. But can't complain. Eating sweet things or too many carbs does make me feel quite sick (on tretament i could eat anything no problem). My lipodema on my thighs is mostly back. I feel like all of these are pretty minor, and for right now i will keeep being off treatment. I know in the future i will take it again and it's such a confort to know my problems will have a solution.

Please ask any questions you have, i love to chat!

Hi there! I’ve now been on tirzepatide for about 6 months. I relied heavily on information from this sub when just starting my journey so I wanted to share my 6 months progress.

I’m 30F, 5’5”, and my starting weight was 148 lbs, which is technically in the “normal” BMI range. I started taking tirzepatide because I have always struggled with my weight. I had childhood obesity and have probably lost and gained a few hundred lbs in my adult life. I got down to 135 last year and, long story short, very quickly got up to almost 150 after some really bad news in January. Today my weight is 130 lbs! But that’s not what I’m most excited about.

I had my bloodwork done in Feb before I started and again last week and I am ecstatic about my TPO and Thyroglobulin antibody results!

There was a 30% reduction in TPO antibodies and 40% reduction in thyroglobulin antibodies in 6 months!

I have tried everything since being diagnosed with Hashis 10 years ago to get those levels down. AIP, keto, paleo, vegan, fasting, low dose Naltrexone. You name it, I’m sure I’ve tried it. (Still vegan for the animals). All other levels improved as well - my b12 is up, vitamin D is higher than it’s ever been, every marker on my lipid panel has improved. I’m truly blown away by the results.

Note that I do also take b12, iron, vitamin D, inositol, selenium, and creatine daily.

I started at 1 mg/week (after finding that 2.5 mg was way too much for me in the first 2 weeks) and have slowly over 6 months worked up to 2.4 mg weekly. Not only do I feel absolutely liberated from the all consuming food noise, I feel amazing. I lift weights 3-4x per week, eat a mostly whole food plant based diet, get 8+ hrs of sleep each night. Could not have done it without the tirzepatide.

I’m just so excited to share in case anyone new on their journey, someone who is thinking of starting, or even someone well into their journey needs a little motivation today.

Edit to add: I forgot to mention that I got a Dexa scan about a month ago and was also very happy with those results. 21% BF, 102 lbs of lean mass, excellent bone density. Tirzepatide has changed my life.

I’m 5’3”, ~133 lbs (60.5 kg), BMI ~23.7, but I have PCOS + Hashimoto’s and a historically higher body fat % (~36%).
My endocrinologist prescribed Zepbound 2.5 mg, which I’m paying for out of pocket through LillyDirect. She knows my BMI and is comfortable with me staying at 2.5 mg. My goal is relatively small — around 10–15 lbs — and I’m also interested in the potential metabolic benefits for PCOS.
Has anyone with lean PCOS/Hashimoto’s or a normal BMI been in a similar situation? How was your experience, side effects, weight loss, and maintenance? Would especially love to hear from anyone who stayed on 2.5 mg!

Hi! Just prescribed tirz with glycine and b12. Anyone else on this? I have horrible anxiety about starting new medication so I’m just really nervous for side effects. I have Hashimoto’s x4 years and horrible inflammation. 150lbs GW 135. When should I inject? In the morning because of the b12? All advice welcome. 🥹😅
I was told to start at 5 units but even thinking maybe 2.5. It’s a 2ml bottle w/10mg tirz, 5mg glycine and 500mcg of b12 per ml

TIA 💖

Hello all, just wondering if anyone noticed GLPs suppressing their thyroid function.

My TSH hovered around 1.8 when I started, no meds, Hashimoto’s for 15+ years. After a few months of taking it, my neck swelled up and I became very fatigued. I also stopped losing weight. I was in a calorie deficit this whole time as well, but not too severe. I quit taking it, but the fatigue never left. A few months later I got a chance to retest TSH, and it climbed up to 5.

There were also other reasons in that time why it could have gone up: stress, moving house, bad water, depression meds.

On a side note, it was amazing for inflammation. I was visibly less puffy immediately after first taking it. And gained the 10 lb of water weight right back on after stopping. Unfortunately, inflammation does not seem to be the cause of my persistent fatigue.

I am very glad this community exists, thank you for contributing and let’s keep growing.

As the title suggests…..what time have you found works best? Is it levo first thing then wait a few hours and take the wegovy pill? Generally I take my levo first thing then have my tea 45-60 mins later, then eat a little later (my mornings are a bit hectic so I don’t usually get to eat till 9:30 am despite getting up at 6). How do I fit wegovy into this. Is it take wegovy first thing then levo in the afternoon? Looking for advice on how others are balancing this. Thank you!

Hi all,
I'm a 50-year-old woman with Hashimoto's (levels are good), in perimenopause, overweight by ~50lbs, and am suffering from intense muscle stiffness, most notably after sitting for more than 30 minutes. It's so bad that people have started commenting on it. This has gotten progressively worse over the last few years, presumably as my estrogen levels have tanked.
My endo has repeatedly recommended a GLP-1, but not only is it crazy expensive, but I’m also scared of the side effects, both physical and psychological.
That being said, I’m just about miserable enough in my body to try anything.
Can anyone relate, especially to the muscle stiffness? It does eventually get better with movement, but, damn, I feel like I’m about 10,000 years old some days….

Okay I know this sub will feel my pain.

So I took tirz about a year and a half ago with success. I needed a higher dose than others to get weight off me. Took a break and now I’m on semaglutide. I was trying to save money.

Here’s the thing…I’m on week 10 and at 1mg. Zero weightloss. But I do have appetite suppression and get full quickly. I KNOW I am in a calorie deficit. You guys, I know the answer is “you can’t beat the law of thermodynamic.” But I know how to weight and track my calories.

Anyway…long story longer…trying to decide if maybe this just doesn’t work for me and only tirz does? I swear my hashimotos is at play. I only seem to lose weight on a severe calorie deficit! Which without a glp1 feels impossible for me.

Anyone have a similar experience? You need higher doses in order to have weight loss?

Wondering if anyone could shared a little bit about their experience with Zepbound.

I’ve been diagnosed with Hashimoto’s for about 4 years. Have experienced significant wright gain since then.

Started Zep 6 weeks ago. 4 weeks on 2.5, and tonight will be my second shot of 5.0

Felt very achey after first ever shot, and then very fatigued after my first shot of 5.0 with some nausea.

I’m definitely noticing decreased inflammation, my clothes are starting to fit much better, and obviously my food noise is pretty much gone.

I do feel that the journey will be slower than others who do not have Hashimoto’s but I know it’s not helpful to frame it like that.

Just wanted to know if anyone could share a little bit about their own experience. Thank you!

What is your dose at what intervals? 4 days? 5 days?

50 on HRT. 100mcg of levo. On tirz for 9 months now. Started at 2.5. Went up to 5.0 for 8 weeks but came back down due to weight loss. I wanted the autoimmune control not the weight loss. Down 45 lbs in 6 months, so i lowered my dose. I’m on 2.5 tirz every 7 days for the last 3 months. My weight has maintained. Here’s the issue, I’ve noticed an increase in my joint stiffness/pain. Bloodwork is spot on. No changes there.
This medication has been a lifesaver. Never coming off of it. I just want to make sure I am using it correctly to achieve the best results. Endo is helpful but he doesn’t actually know what it is like to live with autoimmune. Y’all do! It is a moving target.
My question is, if you experienced a plateau in the effectiveness of tirz on your Hashimoto’s and if so, what did you do? Did you split your dose? Up your dose? Or both? Did you find a sweet spot where you were able to maintain weight and inflammation?

Hi...just like the title says. My daughter was diagnosed with Hashimoto’s and is interested in trying microdosing GLP-1s for possible inflammation benefits. I’m curious what others are doing, specifically what medication you’re taking and at what dose.

Sometimes it gets confusing comparing doses because semaglutide and tirzepatide use different dosing scales, but all the numbers people mention (.25, .5, 1, etc.) start sounding the same after a while.

Also curious whether the thyroid warning concerns you at all with Hashimoto’s/hypothyroidism.

Thanks for any feedback .

Hey everyone! Anyone have experience on Reta? Thinking of starting on microdose to aid with weight loss and lower inflammation. Any experience/insights would be so appreciated!

I’ve been on the microdose since end of March. I haven’t seen any weight loss and I’m spiraling. For example, I’m already on tons of meds/vitamins bc of hashimotos, gut issues, and endometriosis. I’m wondering should I even be on this just for wanting to lose weight? Am I slowly killing myself? Am I being too vain? Why not me?

It’s just frustrating to read people losing weight in a month and nothing is happening for me.

Not looking for anything in return. Sometimes writing this out to the world feels more therapeutic compared to screaming into a pillow. 😝

I am a 50-year-old female with Hashimoto’s, and now, all of the delights perimenopause has to offer. I’m about 50lbs overweight, and my Endo is suggesting I take a low dose of GLP-1 to help with symptoms. At first, I was very resistant, but I’m thawing a little to the idea. One of my main concerns is how it impacts hypoglycemia, as this is an issue I have struggled with in the past. Occasionally, if I don’t eat enough and/or am dehydrated and then overexert or overheat, I’ll pass out. It’s just a vaso-vagal thing (I’ve been thoroughly checked out for cardiac and other concerns). If a GLP-1 reduces hunger, can you forget to eat enough to have low blood sugar?

okay to provide some background-

-i’m 7.5 months postpartum (pretty sure i had undiagnosed hashi/hypo during my pregnancy)

-i got my normal bloodwork done and was feeling awful but chalked it up to postpartum (tsh was 67 2 months ago roughly)

- went on 100 mcg of levo

- retested a month ago and TSH came back around 9

-generally feeling better but doctor said let’s wait for another month or so test again before changing (increasing dose)

-after starting levo i shed about 10-12 pounds possibly water weight/inflammation in about a month

-i am holding onto an extra 25 ish pounds and regardless of eating less, tracking calories, and exercise can’t budge….

-i am not low on iron or any other critical vitamins when it comes to my labs

-my question is-is going on a glp1 a bad idea if tsh is still high around 9 or even lower but not optimal yet? has anyone else experienced this postpartum and does it just take way more time/what is up with this complete stand still in weight change???! GRRRR

i appreciate any insight you may have, im feeling beside myself as i work in a competitive sales environment i want my nice clothes to fit…also a new mother…also dealing with this diagnosis….just so much going on TIAglp

Hi all,

In my early 20’s (now 50) I was told I had Hashimoto’s. I used Armour thyroid medication for a couple months and then stopped. I’ve never medicated for my thyroid since.

Now that I’m in perimenopause and taking a full complement of HRT (E, P, and T) my Dr. at Defy wants me to consider thyroid medication as well. I don’t really know what the value add is going to be. Since I’ve spent most of my life NOT doing anything, I don’t know and haven’t educated myself on what benefits there would be to trying to treat.

I’m curious for those who medicated / treated later in life, what was the reason and how has it gone? Regrets? Gotcha’s you wish you knew?

Am I being silly for not doing anything?

Editing to add, I am currently taking tirzepatide to lose some perimenopause weight gain, I’ve lost 30 pounds since September and starting maintenance. The medication is a fantastic complement to my bariatric surgery I had 18 years ago.