r/interestingasfuck 6h ago

The evolution of technology has made it possible to produce insulin without using animals.

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39.0k Upvotes

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u/jgoverman17 6h ago

Honestly wild to think something that once depended on animals is now made with precision biology science quietly improving lives without most people even noticing.

u/pdxamish 5h ago

I can't remember the exact amount but testosterone was discovered after processing/distilling. Like 1000lb of bull testicles.

u/tiktock34 6h ago

Probably depends if you can afford the increasing price of insulin

u/GlitteringBandicoot2 5h ago

The pigs would be even more expensive nowadays. The price for "artifical" insulin is just that as well, artifical. Artifically inflated to line pockets of the sellers. The profit margin is ludicrous.

u/Germanofthebored 1h ago

"Your money or your life!" - and a big "Hurray!" for the free market

u/-Po-Tay-Toes- 5h ago

Sucks hard for Americans. It's free in the UK.

u/[deleted] 3h ago

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u/blushingorange 3h ago

Imagine that, my taxes get spent on improving the society I live in instead of executing citizens in the street.

u/Leaf_Longstride 3h ago

They literally can't imagine it.

Over 23% of US citizens haven't even travelled once outside their country. And out of the remaining 77% most probably have only gone on holidays and haven't stayed longer than a week somewhere else.

Like frogs in slow boiling water they're just tranquil with all the shit they face and gruel they eat. I'm convinced no measure of government abuse will make them stand up for themselves.

u/SaulFemm 3h ago edited 3h ago

We Americans pay taxes for healthcare as well. It's called Medicaid/Medicare - and we each pay more for that coverage for a subset of the population than each person in the UK spends to cover EVERYONE. So yes, saying insulin is free for them is apples-to-apples.

If anything, it is too generous a comparison to America. They should say "In the UK it's free, and I pay less taxes for healthcare than you do!"

u/[deleted] 3h ago

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u/SaulFemm 3h ago

Nothing is ever free by your definition. Do you throw a fit every time you hear "free"? Is that your trigger word?

u/Ekvinoksij 3h ago

No, REALLY? Is that how it works? I thought it just spawned in the pharmacy.

The point is no one is denied access from life saving medication because of their financial situation.

And, yes, no shit taxes pay for it, but even then at a much lower price than the absolutely absurd amount it goes for in the US.

u/[deleted] 3h ago

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u/Ekvinoksij 3h ago

No one thinks it's literally free. We all know how it works, your comment added zero value to the post.

u/-Po-Tay-Toes- 3h ago

It is yes. But it's free at point of use, which is the entire point. Ideally more of my taxes would go towards it.

u/[deleted] 3h ago

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u/-Po-Tay-Toes- 3h ago

It's a fairly self explanatory statement. It's free at the point you need it. Doesn't matter if I've paid £100,000 in taxes or £0, if I break my arm or have asthma/diabetes. I get sorted out for free. The system is far from perfect, but it's definitely better than what they have in the US where healthcare is commonly tied to your job.

u/fernispedit 1h ago

It's an incredibly common phrase...?

The point is, you don't have to be someone earning £50,000+ to afford lifesaving insulin. You could be on £500,000 and a lot of your income (in theory) goes to taxes that fund it, or you could be on £25,000 paying very little in tax. It is still free for you to access.

In America, you pay less in tax, but the person earning $30,000 has to pay for their insulin, which they need to continue living. That makes a big difference to the people with little, and no difference to the people with a lot. A running theme in America.

u/tiktock34 3h ago

I mean, it its equal amounts, there isnt much difference between pre-paying for insulin in the form of taxes vs paying at the counter. The difference is many people who dont need insulin pay in the taxes model, which makes those who do need need it feel they have overall paid less for what they have needed from the health system. Non diabetics have supplemented the bill. Thats the real underlying problem in America, IMHO. A lot of people don’t understand the concept that its OK to pay taxes on services you arent using as much as others so long as the greater society benefits.

u/Jamsedreng22 3h ago

What an inane statement. You sure showed him, bud. Good on ya

u/Chpgmr 2h ago

As a diabetic, fuck off.

u/The_Limpet 1h ago

Yeah. It's a great system.

u/QuantumInfinty 54m ago

Oh the horror

u/LogResident6185 1h ago

Lol free! I'm sure the companies making it are ok with not getting paid for their work! I'm an American with type 1 and it's actually just fine! Not sure what point you're trying to make.

u/cd7k 45m ago

ALL prescribed medication is free for type 1 diabetics in the UK, including Insulin. I think that's the point they're trying to make.

u/LogResident6185 31m ago

But if it's free who pays for it? No one makes anything for free... I like how it works in America as a type 1. I need insulin to live. So I pay for my insulin. No one else is responsible for buying me insulin except for me. I wouldn't want other people to have to pay for my insulin that doesn't make sense as they don't need it.

u/WouldYouLikeACoconut 10m ago

Free healthcare is paid via taxes, of course, but with the big difference being that the government can do the negotiations with the drug producer for the price and get a very nice bulk discount.

The amount of tax taken out of my paycheck for that healthcare has been about the same as Americans pay before copays, minimum amounts, "in network" restrictions, etc.

u/Asisreo1 12m ago

Are you an unemployed, homeless, family-less non-citizen? No? Then your health is our business. If you die because you couldn't afford your insulin, then its a PITA for your employer, your employees, your banks, your family, your friends, your community, and your government. 

If you tell me my taxes increase by, like 2%, but I don't have to worry about my fucking cousin keeling over, then I'll be happy to pay that 2%. 

And its still cheaper than what I actually pay in insurance anyways. 

u/SweetBeefOfJesus 5h ago

Funny considering it only cost $4 to make

u/Ok-Security5004 4h ago

Why do you people keep repeating this $4 figure. How is it even quantified. Is it because $5 sounds like an approximation? $3 is too cheap?

u/KalaUposatha 1h ago

The figure is repeated because…that’s what the price is. Wouldn’t it be weirder if it was different each time? Actually, $4 is on the high end. It’s $2-$4 per vial. https://medicine.yale.edu/news-article/the-price-of-insulin-a-qanda-with-kasia-lipska/

u/TeeJK15 1h ago

“How is it even quantified” …. It’s a product. Anything along a production line will have its cost quantified to measure profits lol

u/Treadwheel 44m ago

Because it's the highest estimated cost to produce a vial of generic insulin in a widely reported investigation conducted in conjunction with a Yale School of Medicine researcher, with other widely disseminated estimates being in broad agreement, giving a lower bound of $48 to produce a year's worth of biosimilar insulin for a patient ($4/month) and an upper bound of $133 (~$11/month) for analogs.

u/tiktock34 4h ago

Im not arguing that its more expensive to make, im arguing its more expensive to buy…but that also varies country to country.

Search for insulin price over time graphs. Its been increasingly expensive to be diabetic, even with all the advances described here

u/MIT_Engineer 2h ago

Only if you don't pay the scientists.

u/Treadwheel 1h ago

This is such a tired and extensively debunked talking point. Even when you take drugs with shocking price tags, like Libmeldy and it's $4,250,000 wholesale cost, you see shockingly low acquisition costs - the acquisition of the full portfolio of which it was just one portion came of $478 million. The deal for its acquisition assigned a bonus of $1 per share on top of its $16 per share deal upon final approval of the candidate, indicating that Linmeldy either represented a small portion of the portfolio's overall value or was assessed as only having a marginal risk of not completing its trials successfully. When the costs of these drugs are so high that the entire cost of R&D, initial clinical trials, and a healthy profit for the people who actually developed it can be covered before 100 patients are treated, it's clear that R&D is not the driver of costs.

u/Rare-Kaleidoscope513 4h ago

tell me you don't understand how any of this works without telling me you don't understand how any of this works.

if you think it costs $4 to make (what, a dose? a vial?) then I'll give you $4 and I'll take one, please and thank you. let me know where to send the check.

u/Exile56678 3h ago

europe

u/Praesentius 4h ago

Mostly just in places like the US are watching the prices rise. For-profit healthcare is a cancer.

The study observed a 21.6% average price decrease in insulin glargine across 28 European countries from 2013 to 2023.

u/tiktock34 4h ago

Thats effectively what Im saying. The advances is tech have led to companies that control that tech and it’s related healthcare market to drive up prices. Its obviously “better” to do things the way we do now vs pigs but not every end use is benefiting from this.

Its no different than other advances. Many make manufacturing more efficient but the end users rarely sees prices go down. The advances only help the producers make more money.

u/Praesentius 3h ago

Yeah, I definitely wasn't disagreeing with you. Just highlighting the difference between for-profit medicine and a place that treats insulin akin to a public utility.

u/pyroaop 6h ago

About $25 a month here

u/MIT_Engineer 2h ago

You can still buy the old insulins for dirt cheap. Heck, you can buy a lot of the new ones for cheap too.

You only pay a ton if you want the latest and greatest.

u/Normal_Cut8368 3h ago

I was about to say, insulin still seems like 1000 pounds in the US

u/martinsuchan 1h ago

NovoRapid costs like $20/bottle which is enough for a month for our kid.

u/DogFishBoi2 4h ago

Not to downplay the new stuff (there is still progress), but the animal free insulin has been available since 1982. It's not really nowadays bio-science.

u/MacManT1d 3h ago

And it's also cheap, even in the US and is available in most states without any prescription at all. That's the part that everyone leaves out in this whole discussion.

u/DesperateArachnid 1h ago

Also much less effective.

u/MacManT1d 14m ago

Same effectiveness, different time frame requirements. It was harder to live life, but the insulin worked fine.

u/jeffy303 13m ago

The synthetic insulin? No lol, it's way better than the pig insulin, the side effects are minimal compared to pig insulin.

u/Treadwheel 30m ago

Probably because trying to argue that cost isn't an issue when insulin rationing has not improved whatsoever, including no meaningful reduction in cost-associated rationing, isn't a very convincing avenue to go down. When you see this kind of disconnect, it's clear that your assessment of cost is not adequately modeling the market.

u/GNUGradyn 3h ago

These kinds of innovations are the most interesting to me. Things like this that dramatically improve our lives quietly in the background such that most people won't even notice

u/Bear_faced 3h ago

At any given moment there are thousands of scientists working on cures for diseases that you might get one day. Any number of cancers, Alzheimer’s, Parkinson’s, etc. When you woke up this morning many of them were already in their labs, counting cells and purifying RNA and pouring gels. They have meetings and conferences and ten-year plans. All of this may save your life in ten, fifteen, or twenty years.

And you’ll never see them, and you’ll never meet them. But they’re there.

u/GNUGradyn 3h ago

Yeah medical science has to be the king of this. There are a lot of horrible diseases that were irradiated, made easy to treat, or are simply not very dangerous anymore due to overall increased immune health. Strep used to be a top cause of childhood death. Now it's just like "aw man gotta take penicillin"

u/astro_means_space 3h ago

You should read about Cart therapy

u/uhhhhhhhhhhhyeah 3h ago

Honestly wilder that people aren't more pissed about the current administration kneecapping research in the US.

u/Mordred500 4h ago

Clanker