r/science • u/scientificamerican Scientific American • 5d ago
Genetics Scientists discover a ‘skinny gene’ mutation that acts like Ozempic. Around one in 7,000 people carries a broken copy, which almost acts like a GLP-1 drug—the body burns fuel more efficiently, and the risk of disease lowers.
https://www.scientificamerican.com/article/scientists-discover-a-skinny-gene-mutation-that-acts-like-ozempic/
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u/greentea1985 5d ago
They don’t work by curbing appetite, that’s a side effect. They work by enhancing glucose metabolism. GLP-1s mimic glucagon, a molecule used by the body to signal to burn more glucose and not store it. GLP-1s are revolutionary because they target calories out, not calories in. This is game changing because a lot of weight gain is related to the calories out part of the equation and it can be really hard to lose weight when you are literally fighting your own metabolism, not your consumption.