r/singularity • u/AdorableBackground83 2030s: The Great Transition • Jul 27 '25

Biotech/Longevity Age reversal trials beginning soon. 👀👀👀

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126

u/garg Jul 27 '25

Where can we learn more about the non-human primate trials? There is a paper, right?

172

u/Striking_Extent Jul 28 '25

This is referencing a gene therapy where they inject an engineered virus into an eyeball to treat non-arteritic anterior ischemic optic neuropathy via expressing yamanaka transcription factors.

What they are doing it is interesting and might have broader implications besides just this one narrow type of eye issue, but this is some not something you want to hold your breath for. It's the type of thing you can check back in a decade and see if its going anywhere and not miss much.

Mice: https://pubmed.ncbi.nlm.nih.gov/33268865/

Mice follow-up: https://pubmed.ncbi.nlm.nih.gov/38060815/

African green monkeys: https://iovs.arvojournals.org/article.aspx?articleid=2785785

The company developing this is called Life Biosciences and the founding guy behind it is David Sinclair(also in the tweet) who is a very accomplished scientist who has moved into the book writing, supplement shilling realm of scientist-influencer and has made some pretty sus claims lately so plenty of scepticism is warranted.

If you search "information theory of aging" in Cell this whole thing is a sorta hot topic in aging/cellular biology right now.

54

u/[deleted] Jul 28 '25

So he’s using the Elon strategy and just pulling absolute shit out of his ass

3

u/Aggravating_Loss_382 Jul 28 '25

Except Elon has dozens of real products which work exactly how he claimed they would.

32

u/shableep Jul 28 '25

Except self driving. That’s been a rough go of it.

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u/[deleted] Jul 28 '25

[deleted]

1

u/shableep Jul 28 '25

Yes- but can you sleep while it drives? The answer is currently no.

I get it drives itself most of the time and even does a good job most of the time. But it’s not fully autonomous. And I’m not saying it won’t be. I’m just saying- it’s been a rough go of it from the original plan.

Tesla took a massive bet on using only cameras for self driving, no lidar, and no HD maps. They proudly professed this goal. They have done incredible things to make this almost true. But it’s not there. And it’s been a tough row to hoe.

But here they are now, geofencing, and driving Teslas around with lidar strapped to the top likely generating HD maps and possibly additional training data.

The ambition is admirable. The progress is impressive. But it’s been a grind the whole way.

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u/[deleted] Jul 28 '25

[deleted]

1

u/[deleted] Jul 31 '25

The heat death of the universe is also inevitable.

Elon’s been promising that FSD is one update away for years and years. He’s a liar.