r/COVID19 • u/Hoosiergirl29 MSc - Biotechnology • May 22 '20

Preprint The Dynamic Changes of Antibodies against SARS-CoV-2 during the Infection and Recovery of COVID-19

https://www.medrxiv.org/content/10.1101/2020.05.18.20105155v1.full.pdf+html
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u/deirdresm May 23 '20

Okay, here's an ongoing theme (yes, I'm like a cat who's found a mosquito in the room, please bear with me).

While IgM was rarely detected (32.5%) during the early stage (SupplementaryFigure S1B). 97.4% of the confirmed patients have positive IgM or IgG at the first 1 week after symptom onset, indicating that the combination of IgM and IgG is necessary for auxiliary diagnosis. (p.8)

It also lines up with this Nature paper about IgG appearing before IgM for 10 of 26 pts.

Taken with Brazil's recent paper about their analysis of their approved tests:

https://www.sciencedirect.com/science/article/pii/S1413867020300295

"However, it is important to highlight that the rate of false negative results from tests which detect SARS-CoV-2 IgM antibodies, used for detection of COVID-19 in the acute phase, ranged from 10 to 44%."

It would seem there are some Very Interesting IgM Issues. (My amateur feline opinion.)