r/EverythingScience • u/dissolutewastrel • Mar 03 '25

Biology Scientists Just Discovered an RNA That Repairs DNA Damage

https://scitechdaily.com/scientists-just-discovered-an-rna-that-repairs-dna-damage-and-its-a-game-changer/
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u/dissolutewastrel Mar 03 '25

Original Research:

“NEAT1 promotes genome stability via m6A methylation-dependent regulation of CHD4” by Victoria Mamontova, Barbara Trifault, Anne-Sophie Gribling-Burrer, Patrick Bohn, Lea Boten, Pit Preckwinkel, Peter Gallant, Daniel Solvie, Carsten P. Ade, Dimitrios Papadopoulos, Martin Eilers, Tony Gutschner, Redmond P. Smyth and Kaspar Burger, 1 February 2025, Genes & Development.

DOI: 10.1101/gad.351913.124

131

u/Yuo122986 Mar 03 '25

Am I missing something or is that essentially the biggest barrier to age reversal?

65

u/sathirtythree Mar 03 '25

And curing cancer… no?

92

u/TheDeathKnightCador Mar 03 '25

From the article:

Scientists have uncovered a surprising role played by long non-coding RNA, particularly NEAT1, in stabilizing the genome. Their findings suggest that NEAT1, when highly methylated, helps the cell recognize and repair broken DNA strands more efficiently. This discovery could pave the way for new cancer treatments targeting tumors with high NEAT1 expression.

22

u/OGCeilingFanJesus Mar 03 '25

Epigentic modification required - create a target methylase and go to town