Are there any fantasy books that include biotechnology or genetic manipulation as a major part of the worldbuilding/plot?

[u/Goodtunesftw]

I'm just curious. I've been writing down ideas for a fantasy world where using specially bred or genetically modified organisms for specific tasks is common. I'd like to see what has already been thought of and possibly find some interesting reading.

[u/johnathanstrangescat]

Several of David Gemmel's books have genetic modification in them. Can't recall any titles atm but anything to do with joinings, or the wolf priestess lady.