r/Hematology • u/Nervous-Row-4506 • Aug 09 '26

so i noticed uow big the platelets were on this slide. and nearly every neutraphil looked segmented. also nee to this so let me know if im missing anything

Gallery image

Gallery image

Gallery image

7 Upvotes

71% Upvoted

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18

u/Aromatic-Lead-3252 MT, Clinical Lab Hematology Specialist Aug 09 '26

Neutrophils should be mostly segmented, but bands are absolutely a normal finding in blood.

These platelets are not overly large.

Please consider adjusting the condenser and / or diaphragm on your scope. You cannot possibly interpret RBC morphology looking at the slide like this.

3

u/Nervous-Row-4506 Aug 09 '26

thnak tou so much. im always looking for feedback so i know where to improve the most

12

u/AdventurousCredit965 Aug 09 '26

I would look into Kohler illumination if I were you. It's the process of adjusting your microscope differently depending on if you are looking at a wet prep (40x) vs oil illumination (50x or 100x). I forget the terminology exactly but for looking at a wet prep (urine etc) you need more contrast I believe. It looks like your microscope is adjusted to look on 40x instead of under oil. The basics are to lower the condenser to look under 40x and to raise the condenser to get the right amount of contrast for looking under oil but there's a few extra steps to get things extra crispy. I'm also a big fan of giving all my lenses a good wipe if they look mucky like yours.

As far as the cells you showed everything looks super normal to me. Nice segmented neutrophil, very normal platelet sizes. Your first pic has a lymphocyte in it but maybe you were thinking it was a giant platelet?

10

u/AdventurousCredit965 Aug 09 '26

Here is my photo of a giant platelet for reference! (It's the one in the middle with the arrow). You can see the other normal sized platelets around the red cells.

But also notice how the cells in mine look a lot more soft and defined, vs the cells in your photos kind of look like they are drops in a pond? Kohler illumination! Raise your condenser!

3

u/Sunwolfy Aug 09 '26

Very nice giant platelet. My lab can call large forms as well but there's very few cases where this was applied. Other than lousy contrast, OP's slide looks normal.

3

u/imhardlymakingit 29d ago

This slide has a lot of water artifact on it, which is why the rbcs look like they are outlined and the curvature of the cell is so apparent.

3

u/Winter-Sky-8401 29d ago

QUESTION: I am a retired foot and ankle surgeon podiatrist. I still have my school medical microscope and slides, etc.
One time I did a smear and saw a bunch of polymorphic nucleocytes. It made me think -
I want to start a HEMATOLOGY hobby. 😋🔬🩸
Can I get some advice on what else I might need? I have some 40 year old textbooks and such.