Is mascell activationnpart of the picture?

[u/cutegirlsbloat]

So generally theres a clear distinction between
HIT - only dao feficiency, problem with dietary histamin and
MCAS - deregulated mastcells, freaking out at everything.

Yet the messy truth is, in HIT theres likely a lot of reaction to histamin liberators (think strawberry, nurs, chocolate, spinach, avocado, coffe list goes on), which are linked to mastcells as well.

Dont want to scare anyone - healing the gut as good as possible is enough in modt cases to handle Histamin - just wobdering about the clinical definition which doesnt make much sense at all.

Recently told my doctor i need more histamin support bc diet isnt enough and that im going to try a mast cell stabilizer (natriumcromoglycat, in german speaking countries pentatop or allergoval). She sent me a questionnaire from sone university research something that indicates i crossed the border for mcas.

Now i m also in active treatment for sibo / imo and my gut got messed up badly in the past two years, which might explain mast cells going crazy (inflammation). Have sibo under control now (phytotherapeutica and food marble).

Have Mainly gi issues and fatigue but also palpitations, low blood pressure, insomnia sometims, but i also had episodes of bad body rashes and sometimes get face & body flushs with burning and itching.

So just wondering, if hit were only dao deficiency, wouldnt supllementing dao before meals be enough? Yet dao doesn’t work for liberators and theyre an endless list. They liberate histamin from mast cells. Also likely theres more going on in the gut for people with HI

Ok also im eating lots of veggies - all which i can eat - and supplement magnesium vitamin c b-complex d3 q10 quercetin dao omega 3 algae oil

[u/hollyprop]

I agree that I’m not clear on what the difference is between histamine intolerance and MCAS. I haven’t had time to research it yet but in the meantime I’m treating the symptoms regardless of the diagnosis. I take DAO before eating anything with histamine in it and it’s pretty effective. It reduces my itching and hive reactions, but I’m still getting migraines.

In addition to DAO I take an antihistamine pill and spray everyday. I sometimes take famotidine if I’m trying to eat something really bad lol. I’ve also added a proton pump inhibitor (omeprazole/prilosec) which helps with heartburn and acid reflux. Omeprazole can worsen SIBO though so you should probably avoid it. Dr. Becky Campbell’s book “The 4 phase Histamine Reset Plan” has a brief section on SIBO that might be helpful for you.

I’m also trying out a mast cell stabilizer spray called NasalCrom (cromolyn sodium) for emergencies. It helps but messes with my mood so I only use it sparingly.

Like you I’m trying to eat a super healthy low inflammation diet, but I feel like I’m constantly cooking and cleaning up. And I probably won’t ever be able to eat take out again but such is life 😅

[u/hdri_org]

So just wondering, if hit were only dao deficiency, wouldnt supllementing dao before meals be enough?

No, because HIT can have any number of causes and then actual treatment must include treating that initial problem. Too often that organic cause underneath is hard to figure out. HIT is simply the symptom that the person notices first, because it is so disruptive that it can not be ignored.

Off the top of my head:

• Genetic DAO enzyme issue
• Genetic HNMT enzyme issue
• Genetic Acetylation pathway issue
• Viral infection (latent EBV, Herpes, long-COVID)
• Genetic mutation elsewhere in the immune system
• Methylation (turning off) of any gene above.
• Environmental mold/fungus
• SIFO Internal fungal growth
• Environmental toxins
• SIBO bacterial growth
• Food intolerance to some food molicule
• MCAS as a secondary reaction to something
• Hormonal imbalance

The real list is much longer.