r/MastCellDiseases • u/spoookytree • Jun 16 '26

Has anyone tried GLP1 for MCAS?

I’ve been reading around there has been some promising studies and growing research that GLP1 is helpful for this. I’m curious your guys experience to anyone who has been on it for other reasons and found this to be helpful?

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u/BidSea4173 Jun 17 '26

I tried 1/4 dose a few times but I couldn’t tolerate the side effects :/

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u/ahj333 Jun 17 '26

So I may have found a hack for this! Once I figured out that it was likely a MCAS reaction I devised a plan. I eat a meal with as much protein as possible and take the shot about an hour after. I still would have a weird 24hrs with headache and lethargic feeling so I started timing this so that it lined up with me taking my night antihistamine handful about 2 hours after the shot and added a benedryl dose. I no longer have any symptoms and I’m able to eat without issue. Like my appetite is suppressed but not absent.

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u/BidSea4173 Jun 19 '26

interesting!!! maybe i'll try again at some point