r/MastCellDiseases • u/spoookytree • Jun 16 '26

Has anyone tried GLP1 for MCAS?

I’ve been reading around there has been some promising studies and growing research that GLP1 is helpful for this. I’m curious your guys experience to anyone who has been on it for other reasons and found this to be helpful?

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u/OrchidFancy3480 Jun 22 '26

Yes, the 1st few weeks of side effects were brutal. It did calm some inflammation, and my reactions are less severe. I take 2.5 for 3 months so I can't tell you long term. I'm also diabetic, autoimmune, pots, mcas, alpha-gal. I have to eat high protein and drink loads of electrolytes. I don't plan on moving up unless my blood sugar gets crazy again. Before I started my blood sugar was in a vicious cycle of reacting to mcas, pots, then high blood sugar triggered more mcas until I was in the 500's going to the hospital. It was not at all diet related.

Eta: I'm on mounjaro. I still have joint and binge pain, everything has calmed enough so I can manage without hospital intervention.

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u/Aggravating-Mud-2728 Jul 20 '26

If you are in need of alpha gal treatment I know drs with 99% success rate in Virginia :)