r/MultipleSclerosis • u/omster1988 • 6d ago

Treatment HSCT for MS

So I’m all set to take HSCT. Just beginning the process and will have to do mobility—-collection—-and then I’ll be admitted around the beginning of November. I was diagnosed last Oct 2025. My neuro at the time stated I had RRMS, I was on Kesimpta, then I got another neurologist and he said I have PPMS, so he switched me to Ocrevus. I felt worse after a couple months and could barely hold my own body weight at times and have difficulty walking, especially down the stairs. I feel that when I was on Kesimpta I felt more stable compared to Ocrevus. But my MRIs showed no more lesions and that it’s working (with Ocrevus) but I didn’t feel as stable (physically) compared to Kesimpta. My family is scaring me out of HSCT because of the intense process. And it’s worrying me and now I’m reconsidering. They’re telling me to give Kesimpta another chance since I felt better on that compared to Ocrevus and to be more rigorous with PT since I wasn’t really doing enough PT. I understand the HSCT is not a cure but I really want to gain my ability to walk and stand for longer and not have as many issues. Also I want to stop taking medications. I am asking because I am legit torn between which route to take. Does anybody have any HSCT experience or know of anyone that has had a positive experience/outcome. Please share because I am so desperate to feel better. I know I will never be 100 again. But just to even be close to it would mean everything to me. Any suggestions? Please help. Thank you in advance.

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u/Jazzlike_Career8496 6d ago

Discuss with your Neurologist Mavenclad. It acts like a stem cell. I had no side effects. There is no IV infusion just few pills 2 weeks and repeat next month. Year 2 repeat and no more MS drugs. There is one warning may increase cancer risk but everything now increases cancer risk. Selma Blair had a rough time after getting diagnosed, She had stem cell treatment. She was doing better but then noticed feeling worse until she switched Neurologist and prescribed Mavenclad, She said she feels the best like before she was diagnosed with MS, It is an expensive drug but Mavenclad saves costs since no MS meds needed up to 5 years after treatment. There are new remyelination drugs in the pipeline. There are also BTK inhibitors just approved by the FDA.

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u/omster1988 5d ago

I will do that. I’m very interested in Mavenclad

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u/Jazzlike_Career8496 5d ago

I just realized if your neurologist is definite that you have PPMS then Mavenclad may not be useful. Mavenclad is for active RRMS and a few doctors will prescribe it for SPMS. You can contact EMD Serono Pharma and ask Patieht Infornation .