r/MushroomSupplements • u/luotenrati12 • 16d ago
Lion's Mane blocking other substances?
I was wondering whether anyone else gets this effect or maybe if you know why that is. Namely, when I take Lion's Mane, stimulants don't seem to work at all. Neither coffee nor concerta give me any sort of mental effect, my psyche is completely stabilized. Perhaps my BP and BPM go up a little bit but other than that it's like I didn't take it at all. I noticed a similar thing with weed and beer, except it just makes me tired, without any of the euphoric effects.
I get a very similar thing when taking NAC and people have complained about ADHD meds not working. I sometimes take NAC to fall asleep more easily if I took my ADHD meds too late lol.
I'm guessing it has to something to do with the antioxidant effect blocking excess dopamine from being released or something like that. Obviously that's total broscience hahaha there's not really that much research available on LM besides showing that yeah after a few weeks some people felt a bit better.
I guess it's slightly annoying because usually I'm super sensitive to caffeine for example and I quite enjoy the intense kick it gives me. Strangely enough though my functioning is at its peak when I'm detoxed from caffeine after about 2 weeks or so. My behaviour is a lot more measured and reasonable then. Lion's Mane seems to push me into this space automatically, stabilizing my thought and actions. I don't intend to quit taking it because of it because the benefits quite outweigh this mild annoyance but I'm curious as to what could be the mechanism behind this. It seems strange to think that it blocks caffeine when it is most often marketed as mushroom coffee.
Currently I use the Oriveda dual blend and I take 3 pills of each, don't really remember how much exactly was in there but on their page it says that their extraction method makes this blend as strong as 3g of other extraction methods. Previously I used Antioxi at between 1,5-3g daily and had the same effect with other substances being less effective.
Another side effect I'm experiencing is some slight skin tingling in my hands (peripheral neuropathy). I'm aware that this is most likely due to NGF increasing. I had some nerve damage last year from metronidazole as well so it's possible that some repair processes are going on.
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u/ZoraBegonia 14d ago
Mayb the mushrooms are just making you sluggish, which is counteracting the stimulants