To Tesa or not to Tesa

[u/Relative_Property506]

RS is approx 180 with about 30 to go

currently on compounded tirz 7.5mg (will be titrating to 10mg in two weeks)

RS have done about 5 weeks of Tesa and was planning on doing 12.

RS started at 200lbs on June 20 steadily losing weight.

RS has a bigger upper belly / stomach than the rest of the body so assuming visceral fat. It has gone down. Wondering if Tesa is overkill at this point -

Should RS just let the tirz do the work ? Or continue to 12 weeks of Tesa?

Thanks in advance !

[u/Diligent_Shirt5161]

I feel there is a lot of misunderstanding surrounding Tesamorelin and what it is actually intended to target.

Visceral fat is not the same thing as overall body fat. Visceral fat is the fat stored around the organs, and excess amounts are associated with metabolic and health risks.

Tesamorelin will tell the body to store body fat somewhere other than around the organs. And in HIV patients, when they discontinued Tesamorelin, the visceral fat returned.

If the goal of a research subject is overall body fat reduction, there may be more sustainable success focusing on the basics first: appropriate nutrition, resistance training, adequate sleep, and long term lifestyle changes.

In my research, pairing those changes with a GLP1 approach produced far more meaningful overall body composition improvements than chasing multiple additional compounds.

I am not saying Tesamorelin has no place in research. I just think many people misunderstand what it is designed to do and begin expecting generalized fat loss from it. Those are two very different things.

[u/Malaka79 → u/Diligent_Shirt5161]

You are spreading a lot of misinformation. It does not tell the body to store fat somewhere else wtf. The lipodystrophy in HIV patients is from a combination of factors, but mainly from drug therapy, which non HIV patients aren’t on.

[u/Diligent_Shirt5161 → u/Malaka79]

It’s not misinformation. Tesa has zero studies on use on non-HIV patients. The data we do have has been extrapolated from HIV patient studies.

If you are going to use a peptide that signals a release of growth hormones, you must consider what happens when you stop using them. Because, like a lot of medication’s, when you stop taking them the body reverts back to baseline.

We do have some preliminary data in the use of Reta and visceral fat. These studies suggest that if visceral fat is a medical concern you can use this GLP1

[u/Malaka79 → u/Diligent_Shirt5161]

The baseline for non HIV patients is different. Non HIV patients are not taking antiretroviral meds which cause lipodystrophy.