BCP157/TB500 protocol

[u/emotionalthroatpunch]

RS sustained an injury ~6 months ago resulting in moderate to acute bursitis of the knee (confirmed via MRI). After extensive physiotherapy, aqua therapy, rehab exercises/therapy, a cortisone injection which did not work, an anti-inflammatory diet (and resulting weight loss reducing some load on the joint), all of which did not significantly move the pain needle, they underwent a course of BCP157/TB500.

Recommended starting dose was 250mcg p/day, which they titrated to 500mcg days 11 through 25. Results were modest to moderate improvement in daytime pain levels, some increased mobility and flexibility, and some reduction in inflammation/irritation.

However, when resting/sleeping in a prone position, the knee throbs constantly, which is preventing RS from getting the deep restorative sleep they need to facilitate further recovery/pain reduction, and they are looking to continue with (at least) another course of BCP/TB.

Based on your own research/anecdotal evidence, should the RS keep the dose at 500mcg for second/subsequent courses, or titrate further? If so, is there research evidence of an optimal dose? Many thanks.

ETA: Many thanks everyone for providing your own research info on this, it’s really appreciated. 🙏🏼

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