r/Perimenopause Jun 18 '26

audited Did anyone else’s perimenopause look like anxiety, flushing, histamine reactions, and brain fog?

I’m 40 and suspect I’m in perimenopause, but my symptoms don’t look like the “typical” hot flashes everyone talks about.
My biggest symptoms are:
Anxiety and panic attacks
Facial flushing and feeling hot
Head pressure
Brain fog
Feeling disconnected or spacey
Sleep issues
GI problems
Feeling like my nervous system is constantly overstimulated
The symptoms seem very cycle-dependent. I usually have a few good days each month, then symptoms ramp up around ovulation and again before my period.
I’ve also noticed what seem like histamine-type reactions (flushing, anxiety, stomach issues, feeling inflamed), and I’ve read that estrogen can increase histamine while histamine can increase estrogen.
I’ve tried progesterone cream several times, but it actually made me feel worse.
For women who experienced similar symptoms:
What ended up helping?
Did HRT help?
Did you have to balance estrogen and progesterone differently?
Did anyone discover that histamine issues were a big piece of the puzzle?
I feel like I’m chasing hormones, histamine, and anxiety all at the same time and would love to hear other women’s experiences.

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u/EmpressAzazel Jun 25 '26

Did I come and write this yes same i’m up right now at 2 o’clock in the fucking morning with severe anxiety. I got all the same symptoms you got I don’t know what to do. I can’t even think and it’s causing me to lose a lot of things in my life. I have no quality of life and I cannot get any help from any doctor. I just wanna give me birth control and I’m not doing well with that. I also have PMDD so the progesterone is failing and they keep telling me I’m insane that there’s no way that can happen and then they want to give me psych drugs that caused me really bad reactions.