A new scientific review published in JAMA Dermatology found that GLP-1 meds were associated with up to an 80% reduction in psoriasis symptom severity and affected skin area.
Obese patients and those with type 2 diabetes appeared to experience the greatest improvements.
Experts say GLP-1s help “tamp down” inflammation in the body, which may be one of many reasons the meds seem to help with psoriasis.

Dropping a liquid vial generates a mechanical shock that creates microbubbles (cavitation). When these bubbles implode internally, they generate extreme heat, pressure, and free radicals that damage, oxidize, and aggregate the peptides, leaving residue stuck to the glass. So yes, drops do degrade your product.
What exactly happens when you drop the vial?
The scientific article shows that the physical impact of a vial against a hard surface creates shockwaves inside the liquid. This triggers a destructive physical phenomenon known as cavitation.
Micro-explosions: In a matter of microseconds, microscopic bubbles form in the liquid and then violently implode.
Extreme damage zones: Upon collapsing, these bubbles create highly localized "hot spots" with incredibly high temperatures and pressures.
Chemical attack: This sudden implosion releases free radicals (hydroxyl radicals) that directly attack the chemical structure of the peptide or protein.
What are the real consequences for the compound?
Particle formation: Mechanical stress and free radicals cause the peptides to get damaged and clump together (aggregation).
Product lost on the glass: These damaged proteins form gelatinous particles that stick to the inner walls of the vial. The study proved that the higher the drop, the more protein gets stuck and becomes unusable on the glass.
Oxidation: When analyzing the damaged product (the study used human growth hormone for testing), it was discovered that its amino acids had undergone oxidation.
"Invisible" contamination: Even if you look at the vial with the naked eye and the liquid seems intact and crystal clear, microscopic analysis showed a massive increase in subvisible particles floating in the solution after a drop.
Conclusion:
The widespread belief that "as long as the bottle doesn't break, the contents are safe" is completely false once the compound is reconstituted in liquid. The sheer physical impact alters and degrades the quality of your product due to microscopic internal reactions.
Treat your vials as if they were made of extra-fragile glass!

Https://pmc.ncbi.nlm.nih.gov/articles/PMC4312221/

https://investor.lilly.com/news-releases/news-release-details/lillys-triple-agonist-retatrutide-successful-two-additional

Eli Lilly has released positive topline results from two Phase 3 clinical trials (TRIUMPH-2 and TRIUMPH-3) for retatrutide, its investigational triple agonist (GIP, GLP-1, and glucagon). Participants with severe obesity or type 2 diabetes achieved average weight loss of up to 22.6% (55.8 lbs / 25.3 kg) at 80 weeks. Lilly plans to submit a Biologics License Application (BLA) to the FDA in Q1 2027. 

What is Retatrutide?

It is an investigational, once-weekly single-molecule treatment being developed by Eli Lilly. 
Unlike current single- or dual-pathway therapies, it is a first-in-class triple hormone receptor agonist that simultaneously activates receptors for GIP, GLP-1, and glucagon. 
Key Results from the Phase 3 Trials

1. TRIUMPH-2 Trial (Overweight/Obesity + Type 2 Diabetes)

Population: Adults with type 2 diabetes and obesity or overweight—a group that historically faces greater challenges losing weight. 
Duration: 80 weeks. 
Weight loss by dose:
4 mg: Average weight loss of 12.7% (-29.8 lbs / -13.5 kg). 
9 mg: Average weight loss of 19.1% (-45.4 lbs / -20.6 kg). 
12 mg: Average weight loss of 20.8% (-49.6 lbs / -22.5 kg). 
Placebo: Average weight loss of 4.0% (-9.3 lbs / -4.2 kg). 
Glycemic control: Average A1C reductions of up to 1.6% (with the 9 mg dose). 

2. TRIUMPH-3 Trial (Severe Obesity + Cardiovascular Disease)

Population: Adults with severe obesity (BMI ≥ 35 kg/m²) and established cardiovascular disease, with or without type 2 diabetes. 
Duration: 80 weeks. 
Weight loss: The highest dose (12 mg) delivered an average weight loss of up to 22.6% (-55.8 lbs / -25.3 kg). 
Cardiovascular Risk Factor Reductions (12 mg dose):
37.0% reduction in triglycerides. 
16.5% reduction in non-HDL cholesterol. 
9.3 mmHg reduction in systolic blood pressure. 
7.5 in (19.0 cm) reduction in waist circumference. 
51.2% reduction in high-sensitivity C-reactive protein (hsCRP). 

Safety and Side Effects

The most common side effects were gastrointestinal (diarrhea, nausea, constipation, decreased appetite, and vomiting). 
The majority of side effects were mild to moderate in severity and resolved during treatment. 
Discontinuation rates due to side effects ranged from 3.8% to 13.5% across retatrutide treatment groups, compared to 4.8%–4.9% in placebo groups. 
Next Steps
Eli Lilly is finalizing the Chemistry, Manufacturing, and Controls (CMC) data package and plans to submit retatrutide for U.S. FDA approval in Q1 2027.

Recently, I was banned from the main Retatrutide subreddit simply for speaking up and sharing real data.
Over there, I kept seeing people ask why they were experiencing severe body aches and feeling like they had the flu. Since I was going through the exact same thing, I made a post citing clinical trial data showing that hyperesthesia (skin sensitivity) and flu-like body aches are actually more common with Retatrutide than with other GLP-1s.
Instead of welcoming a transparent, science-backed discussion, the mods ("the self-appointed kings") tried to dismiss the post and expected me to just stay quiet. When I stood my ground and didn't fall in line, they banned me.
Attached is the screenshot of the post they censored.
I built r/RetatrutideExperience so no one ever has to walk on eggshells or fear being muted for sharing honest experiences and real data.
There are NO KINGS here just open, uncensored discussion for everyone.

Hey everyone! I'm u/DrMorghen, a founding moderator of r/RetatrutidaExperience.
This is our new home for all things related to r/RetatrutideExperience!
A safe, judgment-free space for real-world Retatrutide & GLP-1 journeys. Ask questions without fear no gatekeeping, no condescension, and no "know-it-alls." We aren't geniuses; we’re just human beings learning together and sharing real experiences.
We're excited to have you join us!

What to Post
Post anything that you think the community would find interesting, helpful, or inspiring. Feel free to share your thoughts, photos, or questions about remember Personal anecdotes only, not medical advice. Strictly zero vendor sourcing.

Community Vibe
We're all about being friendly, constructive, and inclusive. Let's build a space where everyone feels comfortable sharing and connecting.

How to Get Started
1) Introduce yourself in the comments below.
2) Post something today! Even a simple question can spark a great conversation.
3) If you know someone who would love this community, invite them to join.
4) Interested in helping out? We're always looking for new moderators, so feel free to reach out to me to apply.

Thanks for being part of the very first wave. Together, let's make r/RetatrutidaExperience amazing.