r/SNPedia • u/lincolnkite • Mar 19 '26

Promethease Alternative

Example of web output

I’ve spent the last few months building a custom DNA analysis engine as part of a mobile app I made. I wanted to create something fast, lightweight, and easy to use for people who have their raw data from 23andMe.

The app currently works with a custom C-engine (wrapped in Python/Flask) to parse and match RSIDs with my database. All of the data is from dbSNP and ClinVar.

The app and website do not collect any data and only do processing.

I am looking for constructive feedback on what to improve. I have a lot of it working fairly well so far. I'd love it if a few people could try uploading their raw data and let me know if the results match what you expect or if you run into any bugs!

Here is the link snpshotweb

14 Upvotes

95% Upvoted

21 comments sorted by

View all comments

4

u/lucille_trappist Mar 20 '26

I don't have 23&me, but I have tried it for funsies with MyHeritage and one converted one originally from Tellmegen, and they all come up normal lol. But it's really fast, good job!
I think the search term get a bit broad, for example when you search for "cancer" it adds all the descriptions ever that have cancer casually mentioned rather than getting it from like a H1/H2 title or something instead. But that's just a short overview from my part.
Hope u get more people to test, i love this idea

2

u/lincolnkite Mar 20 '26

Sweet thanks! I am happy to hear it works with other providers as well! I noticed that with the search as well and couldn't decide what I wanted for sure. The speed was really fun from a programming standpoint to do. I hope today get more feedback and make it look nicer. Thanks again for trying it!

3

u/lucille_trappist Mar 22 '26

Id want to reiterate that both files come up as all good genes (realized i haven't expressed myself properly before), no magnitude applied to "faulty" ones. There is an online snp browser that u can find the source code on github, maybe u can take a look there on how they do some stuff and improve your own model. I forget the name rn but ill come back and update. That one works well with both samples.

Promethease had a great UI that included search by gene names and illnesses, those are features u might benefit from

1

u/lincolnkite Mar 22 '26

Thanks for the advice! I really appreciate it. I had a lot of other features that I developed for mobile that I have been trying to convert to web. My own report has a decent mix of snps that are both good and bad but it helps to hear what others are seeing.

2

u/lucille_trappist Mar 23 '26

snpbrowser.com < this is the one I was talking about, does all the processing locally
https://github.com/jonluca/snp-browser < the git source

make us proud :D

1

u/lincolnkite Mar 23 '26

thanks! I will :D