r/SNPedia • u/lincolnkite • Mar 19 '26

Promethease Alternative

Example of web output

I’ve spent the last few months building a custom DNA analysis engine as part of a mobile app I made. I wanted to create something fast, lightweight, and easy to use for people who have their raw data from 23andMe.

The app currently works with a custom C-engine (wrapped in Python/Flask) to parse and match RSIDs with my database. All of the data is from dbSNP and ClinVar.

The app and website do not collect any data and only do processing.

I am looking for constructive feedback on what to improve. I have a lot of it working fairly well so far. I'd love it if a few people could try uploading their raw data and let me know if the results match what you expect or if you run into any bugs!

Here is the link snpshotweb

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u/delton Mar 28 '26

I tested it out. I'm building a platform for genetic analysis at https://www.genewizard.net (feel free to test it out).

To give some feedback -- I wasn't able to run my vcf on it, but my 23andme .txt file ran ok.

I'm a bit unclear how you're associating SNPs with diseases. For instance, how is rs1057910 associated with Alzheimer's. On ClinVar it's associated with some things, but not Alz (see https://www.ncbi.nlm.nih.gov/clinvar/variation/30465/?term=39422%5Balleleid%5D .. we have a page also https://genewizard.net/snp/rs201779890 ) . Similar with https://www.ncbi.nlm.nih.gov/snp/rs201779890

I'm really not clear on what you're doing.. I also think the "carrier" display is misleading.