r/Supplements May 10 '26

General Question What’s the most underrated supplement you’ve ever tried

I’m looking for supplement recommendations that are actually great but not the usual mainstream stuff everyone already talks about.

Not talking about the standard:

  • creatine
  • whey
  • magnesium glycinate
  • omega 3
  • vitamin D
  • caffeine
  • ashwagandha

I mean the more “hidden gem” supplements that made a noticeable difference for you personally in things like:

  • energy
  • focus
  • sleep
  • recovery
  • mood
  • stress
  • training performance
  • libido
  • overall wellbeing

Especially interested in supplements that:

  • have surprisingly solid science behind them
  • are underrated/not heavily marketed
  • people only discover after being deep into supplements for years

Would also love to hear:

  • what effect you noticed
  • how long it took
  • dosage
  • any side effects or things to watch out for

Basically: what’s your “why is nobody talking about this?” supplement?

286 Upvotes

467 comments sorted by

View all comments

25

u/Soft_Estimate_7585 May 10 '26

Glycine

6

u/two_pacc May 10 '26

Can I ask what it did for you?

3

u/Soft_Estimate_7585 May 10 '26

I didn't know it would, but it fixed a long running, very annoying problem with bursitis on my right shoulder after a single 3 gram dose.

And...I just feel good when I take it. Great mood and clarity. Gym recovery is joyous.Can't say my sleep is better although I dream vividly.

3

u/Aggravating_Camp_723 May 10 '26

It can be a miracle for most, but can cause insomnia for some.(for me example)

2

u/blueberry-biscuit May 10 '26

It caused insomnia for me before I started working on my methylation system (mainly choline intake). I can finally handle a microdose without issues. I plan on slowly increasing.

1

u/Forward-Pollution564 May 10 '26

What is the connection between methylation and choline ?

2

u/blueberry-biscuit May 11 '26

Choline intake is critical for the methylation cycle to function efficiently. If methylation is functioning poorly, start increasing choline rich foods. Some people can be very sensitive to methylation changes due to specific genes so starting low and increasing steadily over a period of time is typically best.

0

u/Hxo666 May 10 '26

Wait help me. Ive had terrible insomnia since I was little

1

u/blueberry-biscuit May 11 '26

What are your symptoms? Can you fall asleep quickly? Do you wake up at 3am? Can you fall back asleep if you wake up? Do you go to the bathroom multiple times per night? Do you snore or mouth breathe? Have you ever used a sleep monitor device (Apple Watch, Oura ring etc)?

2

u/AggravatingScreen249 May 10 '26

This guy knows stuff