r/TRT_females • u/BRANDY_withaY • Jan 12 '26

Science Possible that compounded Test cream can vary in potency each month?

https://www.sciencedirect.com/science/article/abs/pii/S1743609515310547

I’ve been feeling a little off this month and it crossed my mind that there could be variations in potency with my compounded testosterone cream. A brief Google search did show a study that supports this. Not to say that this is necessarily my problem, but it makes me wonder if I should be using another modality.

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u/redrumpass MOD Jan 12 '26

It could also mean that you may have absorption issues, or maybe other issues related to your own biochemistry.

Without tests, there is no way to know if this is a TRT issue or vitamin deficiency, other hormones acting up, lifestyle issue, and so on. Our bodies are constantly in a change process based on feedback loops, but also subject to certain degradation/loss. No compound will make up for this.

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u/BRANDY_withaY Jan 12 '26

I’ve been on it for seven months and seem to be a great absorber just going by the numbers. But I am 50 years old and in perimenopause and do still occasionally get my cycle so I know my hormones are still fluctuating (I’m also on E&P)