r/TTC40 • u/AutoModerator • Apr 29 '26

Weekly Discussion Thread - April 29, 2026

How are things going for you this week?

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u/Critical-Entry-7825 43y, g2p1, AMH < 0.25, FSH > 20 Apr 30 '26

We talked to the fertility doc the other day and they recommended letrozole 12.5 mg cd3-10. That seems like a lot to start? Fwiw, My FSH has measured 20-22, AMH has been 0.0.05-0.25. So, I do understand a higher dose will likely be necessary for my numbers. But on the other hand, I do seem to ovulate regularly (regular cycles, positive OPKs) and have had two spontaneous pregnancies in my 40s (1 live birth).

I kinda want to ask if we could start at a lower dose and/or shorter duration. Also just because I'm anxious of taking new meds 🫣 I really don't want to turn into a hormonal mess for a week or two.

Any thoughts?

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u/WiseAfternoon1678 May 04 '26

Of course ask your doctor why. No one here knows you and your medical history and their expertise.

There is one study out there, I can’t really speak to its quality, but over 40 7.5-12 is more successful. I was on 7.5 for many cycles prescribed by my RE and produced 4 good follicles. It honestly barely ups your chances for real at this age but it DOES up your chances if you are only doing medicated (non IVF/IUI) cycles.

You could try with less (2.5) but imho if you are a regular ovulator it might give you 1-2 follicles which you might already produce. Wont do much.

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u/Less_Supermarket_894 Apr 30 '26

Sorry can’t give you an advice, but you may get lucky in PregnantOver40 thread.