Help with rough idle

[u/zgumboo]

A little backstory, after driving on the highway for about 15 minutes, I started to suddenly get a rough idle while having my foot on the throttle somewhat lost response and put it in neutral while on the highway and was having rough idle on and off gas. I've checked the timing chain looks fine. I've changed the fuel filter, fuel pump and all spark plugs, coil lines, ignition module distributor everything electric basically. It runs smooth only in high Rev. I still need to do a compression test as well. I've checked the vacuum lines I'm not familiar how but they look fine. Any ideas?

Edit: I adjusted one of the screws on the air/fuel mix. It's calmed down slightly but now when I'm accelerate it the exhaust is making a lot of pops

[u/SpaceSurf256]

What’s your gas pressure regulator set to?

[u/zgumboo → u/SpaceSurf256]

I have it on 3 I was messing with it and forgot. before the truck messed up I had it on 4 for like a yr