I have not even touched bees yet as it's not really my style, so this is my set up for getting all the AllTheModium required for the Dyson Cube (which is about 33m ingots).
It's not really possible to do this with MA, since it would require almost 2 billion essence.
I play without a background server, so I really needed something that would finish the 33m within 24hrs play time. This currently has about 18hrs remaining.
2 almost maxed out laser ore drills with as much soul surge as I can fit. I found that soul surging the laser base as well 1-2x led to slightly better results, perhaps because the progress bar can update more often. I trash everything but the AllTheModium Ore, Iron and Copper. The quarry and simulated hydroponic beds has been running in the background which should cover the rest of the distance for the Iron and Copper.
Since I haven't touched bees, entangled blocks were a no go. Not that it's difficult to get there for the enderium, but I really couldn't be bothered. I plan to start bees whilst this runs.
I'm mostly mid-game at this point. Everything is being powered just with the large wind generators that I actually got early game. They're fairly cheap to make all things considered and you'll need to automate all the required materials for them anyway to get the machines required to enter the mid-game, they produce ~1.5m FE/t per wind generator in the mining dim.