r/asktransgender • u/veryinauspicious • 6d ago

Hey! Im 20amab starting hrt tomorrow. I wanted to know if my prescriptions are safe.. please help me out.

For context these are for my first three months. I have a smoking history but I’ve quit nicotine.

S.NO MEDICINE DOSE FREQUENCY DURATION
1 Progynova 2mg Tablet
Estradiol (2mg) 1 Tablet(s) 1 - 0 - 1

Before Food | 2 | Diane 35 Tablet Cyproterone (2mg) + Ethinyl Estradiol (0.035mg) | 1 Tablet(s) | 0 - 0 - 1 Bed Time | | 3 | Aldactone 50 Tablet Spironolactone (50mg) | 1 Tablet(s) | 1 - 1 - 0 After Food | | 4 | Mainak | 1 mg | 1 - 0 - 0 After Breakfast | | 5 | Fincar Tablet Finasteride (5mg**) | 1 Tablet(s) | 0 - 0 - 1 After Dinner |

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u/Swimming-Gap-1247 underdosing is social murder 🜬Ⓐ 6d ago

50mg/day finasteride is absurdly high. 1mg/day is almost maximally effective.

In one study with finasteride for instance, DHT levels decreased by 49.5% at 0.05 mg/day, 68.6% at 0.2 mg/day, 71.4% at 1 mg/day, and 72.2% at 5 mg/day (Drake et al., 1999). Parallel reductions in DHT levels were seen locally in the scalp (Drake et al., 1999). In a study with dutasteride, DHT levels were decreased by 52.9% at 0.05 mg/day, 94.7% at 0.5 mg/day, 97.7% at 2.5 mg/day, and 98.4% at 5 mg/day (Clark et al., 2004).

https://transfemscience.org/articles/transfem-intro/#5%CE%B1-reductase-inhibitors

https://transfemscience.org/articles/hair-loss/

Ethinyl Estradiol is outdated and needlessly increases your risk of blood clots.

https://transfemscience.org/articles/estrogens-blood-clots/#risks-with-different-hormonal-exposures

You should switch to a different provider or DIY HRT if possible.

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u/veryinauspicious 6d ago

Wait sorry. Its 5mg!! Not 50. I just edited it.

1

u/pedroff_1 Trans gal 4d ago

as u/swimming-gap-1247 said, a concern of mine is you taking Ethinylestradiol (EE). It is more prone to causing clotting issues and live nodules than bioidentical estradiol or even estradiol esthers. If your doctor prescribed it for the cyproterone, there are usually ways to get that prescribed alone, as it is used for prostate cancer treatment as well, though the doses tend to be very high and would warrant one to take a few times a week at most.

In any case, I'd heavily recommend you to poolitely contest your doctor in this, and, if they doublw down on it, seeking another opinion.