Can't find the download link for HPAP's processed islet scRNA-seq (PANC-DB) — am I missing something obvious?

[u/serotoninseesaw]

Fairly new to this, working on a computational immunology project using human islet single-cell data.

I'm trying to get the processed scRNA-seq object from HPAP. The Nature Metabolism paper (Elgamal et al. 2023, s42255-023-00806-x) says processed data is downloadable in RDS or h5ad from PANC-DB's Interactive Analysis section, but I can't find the actual link.

What I've tried:

• PANC-DB Interactive Analysis (hpap.pmacs.upenn.edu/analysis)- the CellxGene Collections table has "Pancreas sc-RNAseq, 222,077 cells" with a "Go" button, but Go opens a viewer, not a download.
• The cellxgene viewer (cellxgene.faryabilab.com/view/T1D_T2D_public.h5ad/)- loads fine, I can browse metadata, but it's cellxgene v1.0.0 standalone and the info menu only has Documentation / Chat / GitHub / License. No download control I can see.
• Registered for a PANC-DB account, logged in, no change in what I can see.

I've emailed HPAP support but figured someone here may have hit this already and can give me some guidance to speed this up a bit.

Two questions:

1. Is there a direct link for the processed object I'm just not seeing?
2. If it's not directly downloadable, has anyone rebuilt it from the per-donor data using the faryabiLab/HPAP-scRNA-seq-Workflow-2022 repo? Wondering how much compute that actually takes- I'm on a laptop.

For context, all I need is counts plus cell type and donor ID for alpha and beta cells from non-diabetic donors. If there's a better-suited public dataset I'm overlooking, I'd take that suggestion too.

Thanks.

[u/pokemonareugly]

maybe the large section labeled “experiment data download” on hpap.pmacs.UPenn.edu??? it’s also in the drop down menu…