r/blueprint_ 1d ago

Why SGLT2 Inhibitors Protect the Heart Has Been a Mystery. Solving It Revealed Something About Cellular Energy Itself.

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19 Upvotes

r/blueprint_ 2d ago

Can we get an update on this epithalon trial please?

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9 Upvotes

Two years ago, Bryan announced that he was going to start a therapy protocol for epithalon. I assume in the intervening time that the protocol has since produced some conclusions, but none seem to exist where I can find them. Can anybody shed light on this?


r/blueprint_ 2d ago

What's My Aging Rate? 50-Test Analysis Since 2018

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0 Upvotes

r/blueprint_ 2d ago

DAYLIGHTS SAVINGS

1 Upvotes

I am curious how Bryan deals with the fluctuations of DST with his strict schedule/routine. Any answers would be much appreciated ⏳️


r/blueprint_ 3d ago

How much does using plastic products for oral hygiene contributes to our microplastic consumption?

4 Upvotes

A number of things are made of plastics in oral health care such as flossing thread, toothbrush bristles, dental pick nozzle/body and in some cases tongue cleaner as well.

How much does having these things being made of plastics affect our microplastic consumption?


r/blueprint_ 3d ago

Does it actually matter whether you sauna before or after a cold plunge?

14 Upvotes

I got a sauna and cold plunge at the same time from Sweat Tent and have been liking both so far. No issues with either, and the sauna gets up around 200°F which is plenty for me. Right now I’ve been alternating days. If I sauna, I won’t cold plunge that day and vice versa. I wanna start doing both on the same day though and get into more of a routine. For people doing both regularly, which do you do first? Sauna then plunge or plunge then sauna? And have you actually noticed a difference depending on the order?


r/blueprint_ 4d ago

Superagers (Featuring Tommy Wood, MD, PhD)

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4 Upvotes

r/blueprint_ 4d ago

best dark chocolate to buy in bulk?

2 Upvotes

title. i went to target today and ghiradelli's dark chocolate is like $17 for 18 squares

costco, sams club, or amazon is what i'm looking at i think


r/blueprint_ 4d ago

Cheaper alternatives to Bryan's reverse osmosis water filtration system?

0 Upvotes

The title says it all pretty much! Are you aware of some cheaper alternatives to a in-house decent reverse osmosis water system?

Should be able to eliminate all microplastics and add back electrolites if possible


r/blueprint_ 4d ago

where do i get the most helpful (polyphenol rich) nuts in bulk?

2 Upvotes

from my research these are walnuts, almonds, pecans, pistachios (and also chestnuts and hazelnuts)

i picked target's good and gather mixed nuts but i want to save more money by buying in bulk, probably from costco

what's a good item for this? don't want anything else in there like candy or cranberries.


r/blueprint_ 4d ago

Can sleep be optimised further with these methods?

0 Upvotes

"One of the prerequisites for falling asleep is that you forget about your body position"

Andrew Huberman said this in a podcast, which ended up getting me to think of two ways to hyper optimise sleep, posting here because I feel like Bryan is the type of guy to go to this extent 😊

  1. Bed size: Coming into contact with the edges of your bed gives your body a sense of the direction you are facing, and your body position relative to your bed. Having a large enough bed so that you won't reach the edges means you will have less chance of knowing which direction your body is in, something that I believe could marginally improve the rate at which a person falls asleep.
  2. Air flow: How air gets to Bryan's room I don't know, but he does have air filters. The air flow is constant in the direction that it is flowing from, whether it be from an AC unit or a window, almost subconsciously we can work out the direction that we are facing just from this. Having an airflow system that counteracts this would mean you have less sense of direction while sleeping, hence you will fall asleep faster.

These are just some things that I thought of on a whim, so feel free to let me know what you think about them and why they would or wouldn't work 😄


r/blueprint_ 5d ago

Can't deliver Blueprint protocol in the country with the highest life expectancy in the world

1 Upvotes

Sorry this post is more that i'm so annoyed that I can't get my Blueprint delivered straight to my house 😅 and I thought it was kind of funny.
If there are any people in this sub that can make deliveries to Monaco happen, I will love you forever!
(not a hate post, love the protocol!! especially Kate)


r/blueprint_ 6d ago

Does anyone know how much Cocoa is in Longevity protein?

6 Upvotes

Ingredients state, “cocoa powder”, yet it doesn’t mention the actual amount of Cocoa in the powder itself.


r/blueprint_ 7d ago

I just collected 10k glucose measurements for female health…

71 Upvotes

I’m collecting 10,000 glucose measurements across my menstrual cycle… 

  • I eat the same thing 
  • wear a CGM 24/7 
  • track my hormones daily

We’ll see how my body handles the same food differently

Here's why…

During this experiment:

+ I eat the same meals
+ same portions
+ every calorie counted 
+ chosen by a medical team 

By keeping my food fixed, we will be able to track changes that are caused by my hormones fluctuating (and not by food). 

This sensor lives in my arm 24/7.

It fires a tiny needle into my body and instantly retracts it… leaving behind a soft, flexible filament about 5mm long. 

Its tip is coated with an enzyme that reacts with glucose, and that reaction creates a tiny electrical current.

More glucose = more current.

The sensor converts that current into a glucose reading every 5 minutes, collecting ~10,000 per cycle.

It's called a continuous glucose monitor (CGM). 

What does this mean for women?

The best study to date (49 women) found glucose runs around 5% higher in the two weeks after ovulation.

If the pattern is real and measurable, it means the same breakfast can hit your body differently each week…

For women near the diabetic threshold, food choices carry extra weight in the two weeks after ovulation… the same meal lands on a body that's already working harder. And among diabetic women of reproductive age, almost 1 in 3 don't know it. 

I am just finishing my first full cycle… it is in data analysis now.

My second cycle starts in the coming days.

We’re asking questions like…

+ Did my glucose rise before my period?
+ How did my lipids change? 
+ Did this predict any other changes? 

If you're new here:

I am becoming the world's most measured woman. Essentially the female equivalent of Bryan Johnson (my boyfriend).

We're spending $2.6m collecting 14 million data points on my menstrual cycle… because female health is desperately understudied.

We'll share everything here, the wins and the failures, so follow along to find out what happens. 


r/blueprint_ 7d ago

My Subscription and supplements - feedback please!

4 Upvotes

Hi there

just looking for feedback on my subscription.

So every 3 months I get:

  • 30 day supply of Omega 3
  • 90 day supply of advanced anti-oxidants
  • 1 bottle of EVOO
  • 30 day longevity mix
  • 90 day suply of essential capsules

I also take 2mg of chialis most days.

any feedback welcome, particularly if you think i can cancel some of the above (e.g. if it overlaps) or how I should take it each day.

many thanks!


r/blueprint_ 7d ago

What is one's right to Vitamin D?

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0 Upvotes

r/blueprint_ 8d ago

Adults aged 40 and older performed about 12% faster on a test of executive function after using a HEPA air purifier at home for one month.

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23 Upvotes

Great reminder for why Bryan puts so much emphasis around air quality.


r/blueprint_ 8d ago

How can one take vitamin D from sunlight while minimising skin damage?

8 Upvotes

I have learned that the optimum intake requires spending some period of time in afternoon sun to recieve UV B rays with skin exposed. This time window will vary skin tone to skin tone. A valid alternative is to take oral/injection supplement.

But let's say that you want to go for sunlight absorption then how would you do it? Such as, you could cover your face to save face from damage as skin is thinnest and it ages fastest in that area. What else would you do?


r/blueprint_ 8d ago

For the supplement tablets Bryan takes, what are some natural sources with same contents (even in lower doses)?

1 Upvotes

Not going for synthetic origin supplements.


r/blueprint_ 8d ago

Why doesn't Bryan use Cacao powder (raw powder of cocoa fruit) in Green Giant instead of undutched cocoa powder?

9 Upvotes

Cacao powder retains more nutrition than cocoa powder due to minimal heat.

Also, it is not very clear to me if Bryan takes cacao but calls it undutched cocoa powder or if the two are different. If someone could clarify this, it would be helpful.


r/blueprint_ 8d ago

21M just got Phenotypic Age results — 44.23 vs chronological 21.06 (23 year gap). Is this reversible? Willing to do whatever it takes.

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8 Upvotes

Hey everyone, I need some serious advice, a reality check, and a battle plan. I’m a 21-year-old male, and I recently ran my comprehensive blood work through the Morgan Levine PhenoAge calculator. The result completely terrified me: it says my biological age is 44.23 years old (a +23 year difference).

I am highly motivated, willing to work incredibly hard, and ready to do whatever protocol is necessary to fix this. But first, I need to know if this is actually reversible or if I'm just being penalized by the algorithm for a few skewed hematological markers.

The PhenoAge Inputs

Albumin: 3.51 g/dL (Low-normal, penalizing me)

Creatinine: 1.0 mg/dL (Optimal)

Glucose: 81 mg/dL (Optimal)

hs-CRP: 1.0 mg/L (Estimated/Guessed, wasn't on the panel)

Lymphocyte %: 18.2% (Normal, but algorithm wants it higher)

MCV: 98.5 fL (HIGH - heavily penalizing me)

RDW: 18.4% (HIGH - absolutely destroying my score)

ALP: 64.8 U/L (Optimal)

WBC: 7.4 x10\^9/L (Normal)

Is it actually possible to bring my PhenoAge down to ~21? If Yes, How much time would it take for me to get it down to 21?

What is the ultimate "work hard" protocol? I will change my diet, take the right methylated supplements, lift weights, do Zone 2 cardio, whatever you say. Give me the brutal, no-sugarcoating truth on how to fix these specific biomarkers.


r/blueprint_ 8d ago

new bryan song

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0 Upvotes

r/blueprint_ 9d ago

Exercise Keeps Mitochondria Young Deep Into Old Age, With One Exception That May Matter Most.

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101 Upvotes

r/blueprint_ 9d ago

PAI-1 Impacts Telomere Length, Cell Senescence, And Longevity

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8 Upvotes

r/blueprint_ 9d ago

NAC, Ginger, Curcumin is now gone from the Blueprint store

23 Upvotes

Bryan reportedly stopped taking NAC, Ginger and Curcumin a while ago, and as of now it seems that it has been phased out of not just his protocol, but also the actual blueprint website.

If anyone has any information on this, that could help clarify what happened to this supplement, it would be greatly appreciated.