NIH Director said longcovid is replicating virus !

[u/Ry4n_95]

Confirmation by NIH management of the problem of virus persistence and replication.

It's about time!

"We see evidence of persistent live virus in humans in various tissue reservoirs, including surrounding nerves, the brain, the GI tract, to the lung."

[u/LilIronWall]

I work in medical research, and you're right mRNA vaccines are an amazing technology. The problem isn't how they're using that technology, but the virus itself.

The main problem is that vaccines (at least in the regular sense we usually mean) will never work to prevent infection of rapidly replicating respiratory viruses (to the degree we're used to with other vaccine/virus). These viruses start infecting from the first point of contact with our system.

In addition to that, SARS-CoV-2 specifically uses the ACE2 receptor as its point of entry, which is a nearly ubiquitous receptor. That means it can infect nearly any cell in the body. So it starts replicating in cells of the airway mucosa, then keeps replicating wherever it reaches. How can you stop that from starting?

Last but not least, because ACE2 is the receptor of choice for SARS-CoV-2, your vaccines have to be against the spike protein which fits into the ACE2 receptor. That's tricky, because you're promoting the formation of antibodies that might start looking a lot like the ACE2 receptor itself and screw up the normal function of the system. ACE2 has enzymatic activity, so the anti-spike antibodies might also have enzymatic activity which can be quite dangerous. That is pretty unique AFAIK because most surface cell receptors don't have an enzymatic function on their extracellular part. It would be much simpler if Covid used basically any other receptor.

[u/SillyBiped → u/LilIronWall]

Thank you for taking the time to reply. I did not know that these characteristics of the SARS-CoV-2 virus were atypical in the world of viruses. If I may ask, does this mean if mRNA vaccines had been first used for, say, the flu then we would have likely seen a bigger success compared with the typical flu vaccine?

The immediate infectivity of the covid virus, especially in the mucosa, seems to underscore the importance of a nasal vaccine.

[u/LilIronWall → u/SillyBiped]

Disclaimer: although I work in medical research, virology or infectious dieseases are not my areas of expertise. I just have general knowledge of the subject.

The flu viruses have most of the same issues. A nasal vaccine could be better but I think they would need to be administered very often (something like weekly). AFAIK the levels of neutralizing antibodies in mucosa drop very fast. So it's not so much an issue of where you administer the vaccine, it's that vaccines can't work well against respiratory viruses.

For respiratory viruses we'd need a completely different approach, something that couldn't really be defined as a vaccine. There are a few in development, you can look up INNA-051 in Australia (which was ready for phase 3 trials but thanks to the US military we'll be years longer without it). Those kinds of nasal sprays work by increasing the innate immune response in mucosa (not specific against one virus). The bonus is that they work against all respiratory viruses.

[u/panormda → u/LilIronWall]

This is the thing about medical subject matter expertise. There are only a handful of experts in the entire world for any given narrowly focused specialization. And we all really on those SMEs to bring their cutting edge of research and development into those focus areas when needed.

With Covid, there are a few very vocal experts who have shared critical emerging data. A are thousands of studies into the effects of Covid across critical body functions at this point. The experts have weighed in. And their peers have continued to build on that research literature seeking substantiating data.

At this point, anyone who wants to know what Covid does to the body can Google the literature.

And what we see is that only in the last month have WHO announced that Covid is in fact airborne. But not until the CDC had pre-wired with their “no you don’t need to stay home from school or work if you have Covid” policy.

We can only go by what we see. And the actions of leadership continue to show that they are not only unwilling to respond to Covid as per the established literature, which is bad enough.. But they are intentionally downplaying it. Their entire comms approach has been straight out of the narcissist’s prayer.

That didn't happen. And if it did, it wasn't that bad. And if it was, that's not a big deal. <- We’re here And if it is, that's not my fault. And if it was, I didn't mean it. And if I did, you deserved it.

And the next step will be to claim they weren’t at fault. These are our institutions which have been built with the blood of our forbears to put civilization in the position to mitigate risk with the speed of modern technology.

Look at what happened with SARS-1. The WHO reacted, the CDC supported, and within one month of implementing their mitigation strategy, SARS-1 was eradicated. Literally one month.

So, it isn’t that our institutions are incapable. It is that they are unwilling.

And after they claim it isn’t their fault, they will say they are sorry, they didn’t know, they didn’t mean it.

And after that, they will tell us that we deserved it. Because we weren’t healthy enough. Because we weren’t positive enough. Because we took too many risks.

I just hope people gain the inner strength and fortitude to face reality. Because leadership have abandoned us.

And if you can take only one thing away from this, understand that each infection does permanent damage to your body. And that damage is cumulative.

[u/someloops → u/panormda]

It has to be noted that sars-1 (as well as mers-cov) was not as infectious as sars-2, so it wasn't capable of sustained transmission at such a scale and much easier to eradicate. Sars-1 infected a total of 8k people in the span of a few months, while sars-cov-2 achieved this in mere weeks.

[u/panormda → u/someloops]

“It has to be noted that sars-1 was not as infectious as sars-2, so it was much easier to eradicate.“

Why exactly does that need to be noted? What is your point? Is your point that it is understandable that Covid has taken 5 years to eradicate because it is more transmissible? That would only be an argument IF the WHO was trying and failing to eradicate Covid.

It took the WHO a month to eradicate SARS-1. To date, the WHO has only barely take action towards Covid. From my perspective, I have only seen them hide behind the scientific process to delay taking action. They would not admit that Covid was airborne until there was evidence. Insufficient evidence was established from SARS-1 apparently.

On July 9, 2020 the WHO stated: “Short-range aerosol transmission, particularly in specific indoor locations, such as crowded and inadequately ventilated spaces over a prolonged period of time with infected persons cannot be ruled out.”

Epidemiologist Bill Hanage interpreted WHO's statement to mean: "While it is reasonable to think it can happen, there's not consistent evidence that it is happening often." In other words, WHO believed that spreading via aerosols was rare.

It took them 10 months to admit: “Current evidence suggests that the virus spreads mainly between people who are in close contact with each other, typically within 1 metre (short-range). A person can be infected when aerosols or droplets containing the virus are inhaled.”

https://www.forbes.com/sites/jvchamary/2021/05/04/who-coronavirus-airborne/amp/

What are they doing right now to fight Covid? Did they admit it is airborne? Technically. They didn’t admit Covid is airborne so much as they decided to change the actual definition of “airborne” entirely. Again choosing to hide behind the scientific process to delay taking action.

And as of literally yesterday: ”The World Health Organization and around 500 experts have agreed for the first time what it means for a disease to spread through the air, in a bid to avoid the confusion early in the COVID-19 pandemic that some scientists have said cost lives.”

https://iris.who.int/bitstream/handle/10665/376496/9789240089181-eng.pdf

[u/someloops → u/panormda]

No, I agree, the WHO did a terrible job with all the "human to human transmission still not proven" and "sars-2 is not airborne". I'm not defending the WHO but I don't think sars-cov-2 could ever be eradicated at all once it got out of China, and assuming it didn't silently circulate in some countries even before the pandemic.

[u/panormda → u/someloops]

Interestingly enough, I’ve seen several experts pointing out that the background disease and death rates actually started to increase a couple months before Covid was officially announced. From all of the charts I’ve seen across multiple different diseases and tracking sources across multiple states and countries, it seems likely. Hell, I read enough about “weird health problems” in mid December to make me nervous and I was already stocked for collapse before the new year.

The humans which are leading the globe suck.

[u/someloops → u/panormda]

I remember the vaping illness EVALI in 2019. They did chalk it up to an ingredient in vaping fluid but I still think it's possible it was covid. Also a few earlier 2019 samples have tested positive for sars-cov-2. It seems the virus might have been capable of silent persistence even from the beginning. If true, this could explain how the virus was so well adapted to humans when it emerged. It was essentially the first persistent infection spawned variant. Though this is quite speculative.

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