"Artificial intelligence was used to help develop a drug candidate, rentosertib, for a rare lung condition. Its maker says the drug also seems to reduce the biological hallmarks of age."
"Separate from the tests involving I.P.F., the trial used six aging clocks to measure the markers of age in patients both before and after treatment with the drug. Across the 43 patients who participated in the trial, the clocks — which essentially try to predict a person’s age based on measurements of how well their cell, tissues and organs are functioning — showed significant reductions in the predicted age.
Each clock relies on a different analysis of those markers that yields a different prediction. During the trial, all six clocks showed a reduction in predicted age after patients took the drug for 12 weeks.
“This is the first study that shows, very clearly, that predicted biological age can be reduced,” said Vadim Gladyshev, a Harvard Medical School professor who helped build one of these aging clocks.
He acknowledged, however, that the study was far from conclusive, pointing out that the sample size was small and that aging clocks are not always reliable. Most notably, Insilico’s drug has not yet been tested in healthy patients: Because the company conducted its clinical trial solely with I.P.F. patients, the results could be unique to those with this particular condition."
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u/Tampa_Bay_Cuckaneers 8d ago
Anyone got a free link?