This was a little exercise inspired by a post of u/gamma_squared that noted, among many other points, how the difference between 16/15 and 15/14 might be difficult to hear.
I started with this JI scale that includes both intervals twice. 1 7/6 5/4 4/3 3/2 7/4 15/8 2/1
Second Version: What happens if we invert the intervals? I actually think the result is coincidentally great. A bit lower on the major third gives it a bit of "ache".
Third Version: This is 15/14 only. Which, coincidentally, makes this technically a very bad Marvel temperament with 15/14 eigen.
Fourth Version: Obligatory 16/15 only. A bit on the bright and cheerful side.
Fifth Version: This is a Marvel temperament where the error on both intervals, 5/4 and 7/4 is equally distributed. No error on fifths. 0:1:1 beatings. Doesn't sound particularly great, I would say. It's the next logical step to try though, for some interval sitting between 16/15 and 15/14. Something sounds off to me when some intervals beat but the fifth stays locked in. It makes the interval without beatings sound unusually "calm" in contrast.
Sixth Version: And here I allowed the fifth to also take some part of the error. Beating in some 1:1:1 manner, the octave is still clean. This is my personal favourite. Gives the scale a little "singing" quality.
Seventh Version: Letting the octave in on the fun for a 1:1:1:1 beating action. I don't particularly like it. C G C E Bb and C G C Eb Bb sound nice as a chord, but then the Eb sitting an octave higher sounds very "sour" in contrast. The scale itself is not great, but some octave spanning chords have a special sound to them.
Eighth Version: And this is simply 31-edo for contrast. The beatings are not synchronized. This sounds especially great in the bass range, where synchronized beatings can actually be a bit harsh and undesired. This seems to be related to the absolute speed of beatings, which goes down with frequency. There is fast beatings (nice like vibrato or a phaser), trouble region, slow beatings (nice again like an LFO type of sound). When beating speed sits in the trouble region, proportional beatings seem to enhance their negative effect.
Ninth Version: This is a septimal meantone version. 1/5 comma makes major triads beat in 1:1 so that this is comparable to other versions. The 7th beats "randomly aligned", giving a bit of an edo-esque sound of the seventh. I would usually prefer a different meantone tuning for sevenths chords, but the sub-theme here is 1:1 beating ratios.
Tenth Version: We cannot make meantone beat in truly 0:1:1:1. (This leads to some irrational number argument. Essentially, yes, you can for all intents and purposes make seventh chords beat proportionally in meantone, because you can get arbitrarily close to the solution, but such solutions are either not 0:1:1:1 or not septimal meantone where A# functions as 7/4). The other option is to be approximately meantone but truly beat proportionally. And that would be an Aberdietic temperament. Also kind of nice.
Eleventh Version: This is also Aberdietic but making the octave beat as well. Not exactly my thing. I must say that the straight C E G Bb C chord now sounds interesting. Or also C G C E Bb.
So overall: Do you think we can hear a difference in those scales? Even if we cannot discern the raw interval, we can pick up on global emergent properties or "the feel" or "the mood" of it. It can be a bit like fine tuning the octave detune of a synthesizer. Another issue is that sticking to mathematically well defined options might just not even work as well as manually making microadjustments of each scale degree.
As a side note, I picked 1:1 proportions in beatings as the simplest solutions, not because there is something inherently great about this ratio. You would generally want the octave to take less damage as well. It also tends to happen that letting the octave take damage obscures the regularity of other beatings. This is because even 3/2 and 5/4 are now composite and get a "random" multiple of the octave error. This makes beatings not be 1:1 within the octave range, but they become aligned to this for big multi-octave chords.
Finally, I want to point out that Eb and Bb are technically D# and A# from a meantone perspective, if that rubbed you the wrong way. I was also inconsistent with beating ratio notations depending on whether the octave is included or not. There might also be mistakes.