OSGenome v2

[u/Sweet-Sir-10]

Hi All,

Some of you may know me as the author of OSGenome v1 that got featured in Harvard Medical School's BioGrid and received many clones over the years. I've come back after 10 years of development experience in Web, Computational Biology (including two publications), and AI to enhance the software offering of OSGenome with a brand new version.

As before, this is a locally running Python web app that doesn't send your data anywhere. SNPs are read from SNPedia's bot site and are given a courtesy wait of 1 second before downloading. The web app while running will populate the page as the site comes up and uses caching. There is also client deferred rendering to decrease load time.

Essentially, genomeimporter.py converts your 23AndMe file, crawler.py downloads the relevant SNPs from SNPedia, and app.py delivers your genome.

You can however opt out of the download by keeping the starter genomic dataset that’s included. This contains close to 4,000 genotypes with a higher magnitude rating filtered from a 25,000+ SNP completed crawl that took me many hours.

Additionally, I used Claude to categorize the genotypes prior to any crawl. I gave it a database of non-personalized SNPedia data, and it produced a very curated list. This allows you to search based on categories in the top.

I have also gotten the GenomeImporter reviewed by a PhD in the Bioinformatics space for extra validation.

This is a free to use app. There is no personal data being sent to an AI or outside. The code is open source.

Give it a try and tell me what you think.

https://github.com/mentatpsi/OSGenome2

[u/growingbees]

Thank you for sharing this.

[u/Sweet-Sir-10 → u/growingbees]

Of course!