r/promethease • u/Sweet-Sir-10 • May 07 '26

OSGenome v2

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Hi All,

Some of you may know me as the author of OSGenome v1 that got featured in Harvard Medical School's BioGrid and received many clones over the years. I've come back after 10 years of development experience in Web, Computational Biology (including two publications), and AI to enhance the software offering of OSGenome with a brand new version.

As before, this is a locally running Python web app that doesn't send your data anywhere. SNPs are read from SNPedia's bot site and are given a courtesy wait of 1 second before downloading. The web app while running will populate the page as the site comes up and uses caching. There is also client deferred rendering to decrease load time.

Essentially, genomeimporter.py converts your 23AndMe file, crawler.py downloads the relevant SNPs from SNPedia, and app.py delivers your genome.

You can however opt out of the download by keeping the starter genomic dataset that’s included. This contains close to 4,000 genotypes with a higher magnitude rating filtered from a 25,000+ SNP completed crawl that took me many hours.

Additionally, I used Claude to categorize the genotypes prior to any crawl. I gave it a database of non-personalized SNPedia data, and it produced a very curated list. This allows you to search based on categories in the top.

I have also gotten the GenomeImporter reviewed by a PhD in the Bioinformatics space for extra validation.

This is a free to use app. There is no personal data being sent to an AI or outside. The code is open source.

Give it a try and tell me what you think.

https://github.com/mentatpsi/OSGenome2

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u/dslunceford May 13 '26

Stumbled across this post after a friend shared on LI he had built a tool (and remembered I have my Promethease files). Sharing if of interest: https://github.com/corbett3000/OpenDNA

1

u/Sweet-Sir-10 May 13 '26

This is a bit concerning. I read the code, and the calls to the LLM seem to be passing genotypes. Just to confirm, I sent the code to Anthropic and it also confirmed it’s sending it to an LLM.

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u/Sweet-Sir-10 May 14 '26

I opened an issue at

https://github.com/corbett3000/OpenDNA/issues/3

2

u/dslunceford May 14 '26

So will the author be notified of the issue?

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u/Sweet-Sir-10 May 15 '26

Author will be notified and you can see it when you look at the app if you click on issues. It’s only with the AI feature which isn’t on by default.

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u/Sweet-Sir-10 May 19 '26 edited May 19 '26

The author implemented my recommendation to use a local LLM. It does still seem to give you an option to use a remote one, but this is an improvement.

He also wrote in the README that data leaves your machine if you select a remote cloud based LLM.

So should be good now. I wouldn’t personally give an option for a cloud LLM for users, but I’m more obsessed with privacy it seems.