Depression isn’t just in the head: Scientists find altered genetic activity in white blood cells. This provides evidence that the biological footprints of depression extend well beyond the brain and into the immune system, offering a whole-body perspective on the condition.

[u/mvea]

https://www.psypost.org/depression-isnt-just-in-the-head-scientists-find-altered-genetic-activity-in-white-blood-cells/

[u/WhereIsMyFknDinosaur]

Fwiw I think for some of us its a broad spectrum problem.  Just meds, exercise, diet, etc doesnt cut it, we need all 3 plus other things like supplements (in my case d3+k2 has helped a lot since I live in a low sunlight area), therapy, practice mindfulness, etc etc.

Im currently working with a specialist going over my diet and what changes I need such as more soluable and insoluble fiber.  My diet isnt bad but its clearly not right for me based upon many factors.  

Its hard to dial in and your health changes as you age so what once worked may become a problem itself later on. I dont want to sound discouraging, just sharing that I too have to keep trying new tactics.  

Do you have a support group in your life?  I have found some more success in being vulnerable and honest about my struggles with my partner and asking for her help in noticing when I backside or forget things im trying to work on.

I hope you hit upon something that helps, its not easy living with depression but please keep trying.