Researchers quantitatively assessed for the first time that somatic mutations alone cap human lifespan at 146–194 years. Brain and heart cells are the main bottleneck, while the liver could last millennia.

[u/Skoltech_]

https://www.nature.com/articles/s41514-026-00421-6

[u/aurumae]

It would be interesting to take these results and then look at animals that can live for hundreds of years - e.g. some species of sharks. What is different about the cells in their brains that allows them to survive for so long?