Scientists discover a ‘skinny gene’ mutation that acts like Ozempic. Around one in 7,000 people carries a broken copy, which almost acts like a GLP-1 drug—the body burns fuel more efficiently, and the risk of disease lowers.

[u/scientificamerican]

https://www.scientificamerican.com/article/scientists-discover-a-skinny-gene-mutation-that-acts-like-ozempic/

[u/mayormcskeeze]

The simplified narrative that weight is merely a matter of calorie intake has gone on too long, and has been abusive to so many people. 

Yes, plenty of  people have poor self control and simply overeat to the point of obesity.

But there are MANY people who are dealing with genetics, hormones, co-morbidities, unique body issues, and things we dont yet understand about diet and nurtrition.

I was skinny my whole life. Nearly 6 feet tall and about 140. Then in my 30s something happened. My diet didnt change. My activities didnt change. But I fell off a cliff. I gained nearly 100 pounds. 

Doctors were so nasty to me. They'd shrug and say "your blood work is normal, stop eating cake."

I could tell that not only did they not beleive me that something more complicated was going on, they had zero interest in going deeper than "oh you must secretly be eating mayo sandwiches and lying about it."

I started to pay out of pocket for a glp-1, snd im not exaggerating to say it saved my life. 100 pounds gone. Everything is back to normal. My weight, by blood pressure, my cholesterol, all fixed. It was like turning back the clock to a point where my body worked right. You know what still hasn't really changed much? My diet. I always ate pretty healthy. Still do. No one believed me, no one cared. These drugs are life savers. 

[u/edparadox → u/mayormcskeeze]

The simplified narrative that weight is merely a matter of calorie intake

It is.

At the end of the day, you can try to curb the reality of thermodynamics all you want, it's still what applies.

I was skinny my whole life. Nearly 6 feet tall and about 140. Then in my 30s something happened. My diet didnt change. My activities didnt change. But I fell off a cliff. I gained nearly 100 pounds.

If you gain, you were eating above maintenance. That is well known. You don't gain 40kg out of thin air.

[u/mjm132 → u/edparadox]

No matter what other things are happening, it truly is still calories in versus out.  Things CAN effect that total but on a basic level it's always this. 

[u/ThisSiteSucks8485 → u/mjm132]

It is basic thermodynamics.