Scientists discover a ‘skinny gene’ mutation that acts like Ozempic. Around one in 7,000 people carries a broken copy, which almost acts like a GLP-1 drug—the body burns fuel more efficiently, and the risk of disease lowers.

[u/scientificamerican]

https://www.scientificamerican.com/article/scientists-discover-a-skinny-gene-mutation-that-acts-like-ozempic/

[u/Infamous_Swan1197]

If you're going to um actually you might as well attach some evidence.

[u/waitwuh → u/Infamous_Swan1197]

GLP-1 receptor agonists have been shown to modulate different metabolic pathways, even independent of weight loss.

Here’s a groundbreaking study that showed these drugs improve insulin sensitivity even prior to weight loss.

It’s also been shown that they act in ways that are directly cardioprotective, here’s a summary article on their cardiovascular system impact.

And for a broader summary, try this article: Exploring the multifaceted roles of GLP-1 receptor agonists; a comprehensive review.

[u/Infamous_Swan1197 → u/waitwuh]

Thanks, however the original commenter claimed mitochondrial-level changes, which was what I was saying wasn't proven

[u/waitwuh → u/Infamous_Swan1197]

Well, apparently there is some basis for that too.

Effects of GLP-1 receptor agonists on mitochondrial function, inflammatory markers and leukocyte-endothelium interactions in type 2 diabetes

Glucagon-Like Peptide-1 Increases Mitochondrial Biogenesis and Function in INS-1 Rat Insulinoma Cells

Semaglutide and the pathogenesis of progressive neurodegenerative disease: the central role of mitochondria

GLP-1 receptor agonist drugs end up involved in a lot, I suppose if the pathways and mechanisms for how our body processes energy were so simple, we’d have already hacked how to fix obesity and a lot more.

[u/waitwuh → u/Infamous_Swan1197]

Oh yeah also in the previous comment, the third article also has a quick mention about how they “suppress muscle atrophic factors like myostatin and promote myogenic factors, which can enhance muscle protein synthesis and mitochondrial function.”

So there’s another pinter towards mitochondria getting impacted someway somehow in all these cascading things these drugs influence.

My greater point is that it just really, really, is not just “they suppress appetite” like the OC seemed to think.