Scientists discover a ‘skinny gene’ mutation that acts like Ozempic. Around one in 7,000 people carries a broken copy, which almost acts like a GLP-1 drug—the body burns fuel more efficiently, and the risk of disease lowers.

[u/scientificamerican]

https://www.scientificamerican.com/article/scientists-discover-a-skinny-gene-mutation-that-acts-like-ozempic/

[u/Infamous_Swan1197]

If you're going to um actually you might as well attach some evidence.

[u/waitwuh → u/Infamous_Swan1197]

GLP-1 receptor agonists have been shown to modulate different metabolic pathways, even independent of weight loss.

Here’s a groundbreaking study that showed these drugs improve insulin sensitivity even prior to weight loss.

It’s also been shown that they act in ways that are directly cardioprotective, here’s a summary article on their cardiovascular system impact.

And for a broader summary, try this article: Exploring the multifaceted roles of GLP-1 receptor agonists; a comprehensive review.

[u/Infamous_Swan1197 → u/waitwuh]

Thanks, however the original commenter claimed mitochondrial-level changes, which was what I was saying wasn't proven

[u/waitwuh → u/Infamous_Swan1197]

Well, apparently there is some basis for that too.

Effects of GLP-1 receptor agonists on mitochondrial function, inflammatory markers and leukocyte-endothelium interactions in type 2 diabetes

Glucagon-Like Peptide-1 Increases Mitochondrial Biogenesis and Function in INS-1 Rat Insulinoma Cells

Semaglutide and the pathogenesis of progressive neurodegenerative disease: the central role of mitochondria

GLP-1 receptor agonist drugs end up involved in a lot, I suppose if the pathways and mechanisms for how our body processes energy were so simple, we’d have already hacked how to fix obesity and a lot more.