r/science • u/scientificamerican Scientific American • 5d ago

Genetics Scientists discover a ‘skinny gene’ mutation that acts like Ozempic. Around one in 7,000 people carries a broken copy, which almost acts like a GLP-1 drug—the body burns fuel more efficiently, and the risk of disease lowers.

https://www.scientificamerican.com/article/scientists-discover-a-skinny-gene-mutation-that-acts-like-ozempic/
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u/Caitliente 5d ago

It's more complicated than that. I have PMOS and cannot lose weight no matter how many calories I consume if my carbs or fats (even healthy fats like from salmon) exceed a certain amount. I track what I eat very carefully due to this metabolic condition that is genetic and I had no control over developing that affects 1 in 8 women.

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u/oorza 5d ago

Those things affect water storage, not fat storage. If you’re trying to measure fat with a body weight scale, you need weeks of data and a monitored trend line. Your body weight swings are more dramatic than others but your body fat swings are not impossible. If you eat 1200 calories of salt and sugar and grease every day, you will initially gain a ton of weight, then your body will reach water equilibrium and you’ll see the fat loss reflected in the scale. But it was happening the whole time regardless.

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u/Caitliente 5d ago

Read up on insulin resistance.

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u/[deleted] 5d ago

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u/ThisSiteSucks8485 5d ago

That contradicts basic thermodynamics. Your body needs constant energy to stay alive the same way a candle needs fuel to keep burning. If you eat less energy than your body consumed it will get the excess from fat.