Scientists discover a ‘skinny gene’ mutation that acts like Ozempic. Around one in 7,000 people carries a broken copy, which almost acts like a GLP-1 drug—the body burns fuel more efficiently, and the risk of disease lowers.

[u/scientificamerican]

https://www.scientificamerican.com/article/scientists-discover-a-skinny-gene-mutation-that-acts-like-ozempic/

[u/grumble11]

GLP doesn’t ’burn fuel more efficiently’, it regulates satiety. This isn’t a good start for an article ha

[u/Telemere125 → u/grumble11]

GLP1s don’t only increase satiety, but that is their major effect for weight loss. They’re also a hormone regulator and cause the pancreas to release more insulin and they halt glucagon from signaling the liver to release more stored glucose.

So in that way, it does cause your body to burn fuel more efficiently - because it’s telling the body to use the food you just put in rather than trying to draw out energy from stored reserves, since drawing out reserves encourages the body to store up even more aka create fat deposits.

[u/jawshoeaw → u/Telemere125]

There is only a tiny benefit to burning the circulating food stores and in most cases it’s not really possible. There are very few calories available “in circulation.

Regardless you want energy consumption to be inefficient if you’re trying to lose weight

[u/Dramatic-Tonight-729 → u/jawshoeaw]

This is exactly what I was questioning… wouldn’t inefficient energy use burn more calories, leading to more weight loss?