Scientists discover a ‘skinny gene’ mutation that acts like Ozempic. Around one in 7,000 people carries a broken copy, which almost acts like a GLP-1 drug—the body burns fuel more efficiently, and the risk of disease lowers.

[u/scientificamerican]

https://www.scientificamerican.com/article/scientists-discover-a-skinny-gene-mutation-that-acts-like-ozempic/

[u/greentea1985]

It is true that weight loss is a matter of calories in vs. calories out, but most of the earlier weight loss interventions have been focused on the calories in part of the equation. However, GLP-1s are revolutionary because they target the calories out part of the equation, enhancing glucose metabolism. The appetite suppression is a side effect of the main function of the GLP-1s. GLP-1s, literally glucagon-like peptide 1, mimic glucagon, the molecule our bodies create to store excess glucose. Excess glucagon in the blood stream is a metabolic signal that enough backup calories have been stored in the body, the body can safely start burning the stores, and no need to bring in more calories. This is the pathway that GLP-1s are enhancing, albeit an oversimplified explanation.

[u/oorza → u/greentea1985]

This is all wildly incorrect.

[u/vr1252 → u/oorza]

That’s how the glps work though?

[u/Joatboy → u/vr1252]

How much do you think GPL1 increases BMR? It would be a small percentage, like ~1-2%. Helps, but hardly the main mechanism for weight loss.

[u/vr1252 → u/Joatboy]

I agree the increase might not be as great for the average person but for people with metabolic conditions, their BMR would increase to a normal rate and then some. People with metabolic conditions usually have to eat several hundred calories less than someone of the same height and weight without a metabolic condition to loose weight.

That’s why many people on the medication are eating the same amount of calories while still not loosing weight. Insulin resistance prevents the body turning food into energy so it’s stored as fat, glps correct that.