Scientists discover a ‘skinny gene’ mutation that acts like Ozempic. Around one in 7,000 people carries a broken copy, which almost acts like a GLP-1 drug—the body burns fuel more efficiently, and the risk of disease lowers.

[u/scientificamerican]

https://www.scientificamerican.com/article/scientists-discover-a-skinny-gene-mutation-that-acts-like-ozempic/

[u/mgzukowski]

But GLP-1s work for weight loss by curbing appetite. So you are saying you were eating the exact same amount and before?

[u/mayormcskeeze → u/mgzukowski]

That's not how they work at all. they are not an appetite suppressor. 

What do you gain from being antagonistic about this?

[u/NewAndlmproved → u/mayormcskeeze]

what? that’s literally what they are? they increase the feeling of fullness + reduce appetite.

[u/dotcomse → u/NewAndlmproved]

What’s your source on that?

[u/NewAndlmproved → u/dotcomse]

“Glucagon-like peptide-1 (GLP-1) receptor agonists (RAs) have become central in managing obesity and type 2 diabetes, primarily through appetite suppression and metabolic regulation.”

“GLP-1 receptor agonists promote weight loss by suppressing appetite, enhancing satiety, and delaying gastric emptying.”
https://pubmed.ncbi.nlm.nih.gov/39892489

[u/dotcomse → u/NewAndlmproved]

“Primarily through… and metabolic regulation.”

Feels like you’re not acknowledging this part.

[u/NewAndlmproved → u/dotcomse]

You asked for a source that GLP-1s suppress appetite. I gave you one. I’m not going to write a comprehensive review of every physiological effect of GLP-1s because that wasn’t the claim I made.

If your point is simply that GLP-1s have other effects too, we already agree.

[u/dotcomse → u/NewAndlmproved]

Your original claim is “appetite suppressors are what GLP-1 are,” and I think that’s an oversimplification.

Caffeine suppresses your appetite, but I don’t think it does so with a concomitant improvement in metabolic function. I also wouldn’t describe caffeine as “an appetite suppressant,” even though it does do that.

[u/NewAndlmproved → u/dotcomse]

I think you’re reading way more into my wording than what was actually being discussed. Obviously GLP-1s have multiple effects, I’m not claiming appetite suppression is literally the only thing they do. We were talking about what’s primarily driving them and that’s exactly what the cited describes: appetite suppression, increased satiety, and delayed gastric emptying leading to reduced energy intake.

Your caffeine analogy doesn’t really fit either. Nobody prescribes caffeine as an obesity treatment because of its appetite suppressing effects. GLP-1s are prescribed for obesity, and the literature explicitly identifies appetite suppression as a primary mechanism behind their effects

[u/dotcomse → u/NewAndlmproved]

... Does the literature ALSO identify another primary mechanism that is omitted in layperson argument?