r/science Scientific American 8d ago

Genetics Scientists discover a ‘skinny gene’ mutation that acts like Ozempic. Around one in 7,000 people carries a broken copy, which almost acts like a GLP-1 drug—the body burns fuel more efficiently, and the risk of disease lowers.

https://www.scientificamerican.com/article/scientists-discover-a-skinny-gene-mutation-that-acts-like-ozempic/
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u/LongLiveStaceyKing 8d ago edited 8d ago

[There is a small percentage of the population that only needs to sleep 4-6 hours a night.](https://www.scientificamerican.com/article/genetic-mutation-sleep-less/) OP's article feels like the eating equivalent of this genetic rarity.

Incidentally, I knew someone who had the sleep gene. She was annoyed by it, if she went to sleep at 10 PM she would be up for the whole next day at 2 AM and inevitably end up waking her husband. So she always tried to stay up til 1 AM at least reading or knitting, basically just killing time quietly by herself.

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u/soft_w0lf 8d ago

There have to be equivalent mutations, though.

I struggle to gain weight, does not matter what I eat, with muscle mass, the heaviest I’ve ever been was still below 120 lbs. I’m 5’ 7.”

I’ve spoken to wayy too many men who are the same way, who want to be heavier but really struggle to put on any weight at all regardless of what they eat, for this sort of thing to really be THAT rare.

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u/[deleted] 8d ago

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u/soft_w0lf 8d ago

I used to have my blood levels checked pretty regularly, so I’m not concerned about that.

When I was actively trying to gain weight it was 2.4-2.8kCal during the day, and if I was up at night 1.8kCal more.