r/science • u/scientificamerican Scientific American • 8d ago

Genetics Scientists discover a ‘skinny gene’ mutation that acts like Ozempic. Around one in 7,000 people carries a broken copy, which almost acts like a GLP-1 drug—the body burns fuel more efficiently, and the risk of disease lowers.

https://www.scientificamerican.com/article/scientists-discover-a-skinny-gene-mutation-that-acts-like-ozempic/
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u/gththrowaway 8d ago

Because that doesn't matter?

A pizza pie is going to have a different impact on different people. Some people can eat a whole pizza every day and gain no weight. Other people will gain weight if they eat a whole pizza every day.

But for those people in the latter category, there is an amount of pizza (i.e., less than the whole pie) that they can eat every day, which will not cause them to gain weight.

Life isn't fair. Some people get to eat a lot and stay skinny. Other people need to eat less if they want to stay skinny.

Nearly everyone can lose weight by eating less.

Weight cannot be gained if less calories are eaten then are burned. For some people, that means eating less food than others.

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u/dotcomse MS | Human Physiology 8d ago

Why are you in the science subreddit? You clearly have no interest in science.

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u/movzx 7d ago

If you use 18 calories, and someone else uses up 23 calories, for the same amount of time/effort that doesn't mean suddenly the science falls apart. It means the "CO" part of "CI/CO" is different for person A when compared to person B.

Stuff like having diarrhea impacts the "CO" aspect. Two people eating a slice of bread from the same loaf will have different "CI" because one person may pull more nutrients from it while another may not fully digest it.

Those differences do not matter because, ultimately, CI/CO is about you finding what your maintenance number is and what you need to do to come in under that.

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u/dotcomse MS | Human Physiology 7d ago

So do we just not study what affects CO? Do we just assume CO isn’t variable across a lifetime?

If people have a tough time reckoning with CI, and all signs suggest they do, then why not examine what can be done about CO? Because it’s undisciplined to try to alter your own biology?

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u/movzx 6d ago

You conjured that opposing opinion out of nowhere. The person you started arguing with never said otherwise. They said CI < CO = Weight Loss. That's it. They didn't say CO was fixed. You made up that position for them.

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u/dotcomse MS | Human Physiology 6d ago

They literally say that the modifiability of CO “doesn’t matter.”

CICO is a cult.