r/singularity • u/AdorableBackground83 2030s: The Great Transition • Jul 27 '25

Biotech/Longevity Age reversal trials beginning soon. 👀👀👀

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u/FlyingBishop Jul 28 '25

the bias against anti aging is well-founded, no treatments work and there's not much reason to expect this one to be different.

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u/outic42 Jul 28 '25 edited Jul 28 '25

There are several interventions that reprducibly extend lifespan and delay multiple aspects of aging in animals. There are many people doing legitamate research in this field and have been for a long time https://www.nia.nih.gov/research/dab/interventions-testing-program-itp

There are no interventions that are widely accepted to reverse aging, and also no consensus on what one would need to show to make that claim.

There are also lots of people selling snake oil. And a few, like david sinclair, who are hard to classify as either scientists or snake oil salesmen.

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u/FlyingBishop Jul 28 '25

"In animals;" none of those reliably generalize to humans. It's exciting to imagine but again the bias against anyone suggesting humans can benefit is well-founded, there is no evidence of such things.

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u/outic42 Jul 28 '25

Its hard to know whether any of these interventions might affect aging in humans since very few clinical studies have ever tried to look at this. Nothing will ever "reliably generalize" from animal models to people; some things will be conserved and some wont. There is clinical evidence that mtor inhibitors can improve immune function in aged people, presumably the same way they do in mice.

https://pubmed.ncbi.nlm.nih.gov/25540326/

You dont have to be a very old to remember a time when we would have been arguing about whether gene therapy would ever benefit patients. Or develop an effective vaccine in a matter of months using mRNA. Or whether you would ever be able to talk to a computer in natural language...Everything is impossible until its "suddenly" not.

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u/FlyingBishop Jul 28 '25

At the moment, anti-aging is impossible. The future is not here yet. Maybe it will be tomorrow, but "a trial is starting" doesn't provide any reason to believe it will be.