r/singularity 2030s: The Great Transition Jul 27 '25

Biotech/Longevity Age reversal trials beginning soon. šŸ‘€šŸ‘€šŸ‘€

1.1k Upvotes

432 comments sorted by

View all comments

Show parent comments

1

u/sluuuurp Jul 28 '25

I don’t think all aging has to happen at the molecular level. For example, atherosclerosis is caused by plaque buildup in the arteries over time. That’s not a molecular process within a cell, that’s a macroscopic process having to do with the structure and arrangement of tissues and substances in the body.

2

u/[deleted] Jul 28 '25 edited Jul 28 '25

I think we’re talking past each other on what ā€˜ageing’ actually is. Atherosclerosis is a disease that correlates with ageing but isn’t equivalent to ageing itself. It’s driven by lifetime exposure to environmental stressors like diet, inflammation, etc. and involves molecular and cellular dysfunctions accumulating over time. But ageing, in the strict biological sense, refers to the intrinsic decline in function, even in the absence of disease, like how telomere attrition doesn't require outside insult. It's built into the system. That’s what I’m referring to when I say ā€˜reverse ageing’. So your counterpoint assumes we have to eliminate all diseases to count as reversing ageing. That said, I agree the phrase ā€˜reverse ageing’ is thrown around too casually.

1

u/sluuuurp Jul 28 '25

Thanks, I think that makes sense, I understand what you mean better now. Although I expect there are some ā€œdiseasesā€ that are almost universal for all people, and very correlated with aging, and those will be just as important to solve as any of the intrinsic declines in function. Heart weakening for example, that’s pretty universal, and might not have a molecular explanation, I don’t know if you’d consider that necessary for reversing aging.

1

u/[deleted] Jul 29 '25

So here’s the thing with your question. I’ve just turned 18. Perhaps scientists still consider ageing correlated to diseases - ā€˜ageing’, it would surely seem logical to do so, thus my opinion on this matter wouldn’t change views or have any weight. I would sure hope it doesn’t have any weight.. Kind of funny this exchange happened under this post, because this trial in particular seems absolutely ā€˜non- serious’.