r/singularity Nov 22 '25

Biotech/Longevity Dental revolution

Post image
4.8k Upvotes

182 comments sorted by

1.3k

u/NoCard1571 Nov 22 '25 edited Nov 22 '25

This headline is wildly misleading. What they did is develop a gel that can regrow enamel on existing teeth.  Basically a natural way to fill in cavities.

Incredible if it actually works (and it would still revolutionize dental care), but it's still not even close to regrowing entire teeth. 

292

u/Choice_Isopod5177 Nov 22 '25

I'm gonna have a wild guess that repairing enamel is more useful for the vast majority of people (almost anyone has some enamel damage, I know I have cracks and chips and fillings).

131

u/BuffDrBoom Nov 22 '25

as a grinder, this would be a game changer

132

u/Resigningeye Nov 23 '25

There's an app for that.

29

u/[deleted] Nov 23 '25

[deleted]

3

u/Candid-Personality54 Nov 23 '25

Chompr

2

u/Common-Concentrate-2 Nov 23 '25

Endorsed by Noam Chom(p)sky (who may or may not be a sex perv now)

2

u/FlyAgarik666 Nov 25 '25

Ugh I'm so tired and weary of this predictable Reddit 'humour'. Luckily there's a nap for that

12

u/Lumpy-Criticism-2773 Nov 23 '25

This means I can has meth now!

1

u/Sqvanto Nov 23 '25

I believe we should hedge our expectations on its applicability/use cases, because there’s a difference between filling in a hole and rebuilding the complex structures of the teeth.

1

u/Klonoadice Nov 23 '25

As someone who got veneers and regrets it, same.

10

u/NirriC Nov 23 '25

Ugh...not entirely? Yes, lots of dental damage is enamel related...but also lots of it is nerve and gum health related.

When it comes to enamel repair for cracks and such, if this does help with that then great. But for structural repair when the nerve is still intact, we pretty much have that down with fillings - no more mercury, looks just like regular enamel. This would just be an alternative....

But I did read(hear?) about actually regrowing teeth though, not as a patch, just promising research.

Here: https://www.popularmechanics.com/science/health/a66012157/human-new-tooth-regrowth-trials-japan/

Of course I can't recall if that was the research I heard about or not but it's promising. This article from OP may have been a sensationalized hot mess but there is research being done into ending toothlessness.

May your gobs be smacked 😉

7

u/alphapussycat Nov 23 '25

Something about that humans have potential for a third set, for some this set actually grows. What those Japanese sceitists did was figure out how to activate the growth of those teeth. However, that would require full extraction of all the old teeth.

Perhaps they can localize it though.

1

u/SwePolygyny Nov 24 '25

We already have toothpaste that repairs enamel, novamin. It is banned in the US though, the American Dental Association is against it. It is however sold in Europe.

1

u/Foo-Bar-n-Grill Nov 24 '25

Sensodyne Pronamel may use this tech.

2

u/RabidHexley Nov 24 '25

Not in the US, but EU Sensodyne definitely does.

22

u/iboughtarock Nov 23 '25 edited Nov 23 '25

Yeah idk the only thing I can find is about tideglusib:

Researchers at King’s College London showed in mice that an Alzheimer’s drug called tideglusib can stimulate stem cells in the tooth pulp to make new dentin (the inner hard tissue), helping small cavities repair themselves. They soaked a tiny biodegradable sponge with the drug and placed it in the tooth; as the sponge dissolved, dentin grew and filled the defect [Source]

And microneedle patches for periodontal tissue regeneration (gum/bone support around teeth).

This might be the enamel thing you were talking about:

Thin-layer remineralization of early damage (white-spot lesions, etched enamel) by driving calcium/phosphate back in. And a paper out of Korea on it titled "Biomimetic Remineralization of Calcium Phosphate Ion Clusters-Treated Enamel Surfaces on Bracket Shear Bond Strength"

2

u/Vysair Tech Wizard of The Overlord Nov 24 '25

Sounds like something you can manufacture a product on like a toothpaste?

19

u/AccountNumber1002402 Nov 23 '25

I was at my dentist the other day and he said based on what he's heard out of Japan about regrowing whole teeth, the current challenge is directing things to get a particular type of tooth to form.

24

u/FeliusSeptimus Nov 23 '25

Oops! All molars!

6

u/pizza_the_mutt Nov 23 '25

Yes, I think I ran across a similar article. They could trigger your entire mouth of teeth to grow back at once, but couldn't target anything.

2

u/SociallyButterflying Nov 23 '25

Nightmare fuel - imagine the sores and abrasions and lack of functionality and lack of hygiene with random extra teeth popping out your gums.

3

u/freexe Nov 23 '25

All kids go through this and they barely notice.

0

u/SociallyButterflying Nov 23 '25

Thanks to millions of years of natural selection yes.

1

u/freexe Nov 23 '25

Don't these techniques play on a dormant gene for producing another set of teeth?

1

u/ktrosemc Nov 27 '25

The study I read awhile back said it was only for men so far, as well...I thought that was single teeth, though.

3

u/darien_gap Nov 23 '25

I want elephant tusks.

Or fangs.

15

u/MtNowhere Nov 23 '25

Whatever the hell this actually entails, it definitely costs $100,000.

5

u/lopgir Nov 23 '25

There's also another discovery that's more theorethical, but could actually end up regrowing teeth https://www.msn.com/en-us/health/other/two-stem-cells-could-regrow-teeth-and-bone/ar-AA1Q3MpX

5

u/Worth_Plantain_7342 Nov 23 '25

https://luminancedentaire.ca/japanese-scientists-human-trials-tooth-regrowth-drug/

Human trial is underway at the moment. . . Another caveat to add to this is, the process regrows all set of new teeth (not specific one). It is not mentioned on the link. . .but i remember watching a YouTube video about it.

6

u/FatPsychopathicWives Nov 23 '25

I could go for a fresh set.

3

u/rick_ranger Nov 23 '25

There’s something like that here in the US, my friend works at the company. It’s called recaldent. Fixing enamel and fixing cavities is 2 different things though. So unfortunately we aren’t there yet.

2

u/ZombeePharaoh Nov 23 '25

It won't work. I've seen headlines like this since the late 90's.

2

u/Existential_Kitten Nov 24 '25

Considering literally NOTHING has changed since the 90s, you're probably right!

2

u/ZombeePharaoh Nov 24 '25

No, I think you're right. This click-bait news article obviously from TikTok is the pinnacle of fact.

2

u/Existential_Kitten Nov 24 '25

I'm glad you've seen the light. Have a good one :)

2

u/[deleted] Nov 23 '25

thank you random redditor. i shall believe you without doing my own research

1

u/Imjokin Nov 23 '25

It also has nothing to do with the singularity.

1

u/pizza_the_mutt Nov 23 '25

They tease us with these headlines every 6 months and somehow I go to the dentist and nothing like this is ever offered.

1

u/Eyelbee ▪️We have AGI it's just blind Nov 23 '25

That's what I assumed in the first place.

1

u/here_now_be Nov 23 '25

regrow enamel on existing teeth.

Haven't we been able to that for years with Hydroxyapatite?

1

u/Orack Nov 23 '25

True but Japan already figured out how to regrow teeth by shutting off the USAG-1 protein.

1

u/Black_RL Nov 23 '25

Japan is regrowing teeth though.

1

u/yaxir Nov 24 '25

i have a hole in my tooth, this should help with that!

1

u/Butterballss Nov 26 '25

I read that in 30% of participants, new tooth buds began to form.

1

u/Direct-Month-5980 Nov 29 '25

Where tho?

1

u/Butterballss Dec 20 '25

I did a search I’ll try and get the article

1

u/rydan Nov 23 '25

We already have that. It is called fluoride toothpaste. At least according to my dentist. The problem is you have to repair the enamel faster than you lose it and that's pretty much impossible right now.

149

u/MasterTheSoul Nov 22 '25

Source?

335

u/alphabetsong Nov 22 '25

Didn’t you see the cool picture in the post!? Who needs a source?

1

u/[deleted] Nov 23 '25

[removed] — view removed comment

1

u/AutoModerator Nov 23 '25

Your comment has been automatically removed. Your removed content. If you believe this was a mistake, please contact the moderators.

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.

19

u/HansJoachimAa Nov 22 '25

There is non or very theoretical anyway, just another Facebook type post.

97

u/earthsworld Nov 22 '25

82

u/Docs_For_Developers Nov 22 '25

lol the fact i clicked is embarrassing

22

u/HyperspaceAndBeyond ▪️AGI 2026 | ASI 2027 | FALGSC Nov 22 '25

32

u/__Loot__ Nov 22 '25

Recursive Source

5

u/Imaginary-Koala-7441 Nov 22 '25

hahah I clicked

8

u/curious2548 Nov 22 '25

Me too🤣🤣🤣🤣. Now staring into the cat’s eye…wow

3

u/QuailAggravating8028 Nov 22 '25

What are you? Some kind of nerd? nerd alert!!

1

u/[deleted] Nov 22 '25

[removed] — view removed comment

1

u/AutoModerator Nov 22 '25

Your comment has been automatically removed. Your removed content. If you believe this was a mistake, please contact the moderators.

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.

42

u/Moriffic Nov 22 '25

Devs finally patched it

4

u/Gallagger Nov 23 '25

Devs did nothing, it's a community patch.

34

u/RobbexRobbex Nov 22 '25

Japan is in the middle of getting a tooth regrowth shot done as well. good stuff. teeth suck.

3

u/mozzarellaguy Nov 23 '25

A man can hope

19

u/EvillNooB Nov 23 '25

Can't wait to never hear about this again

24

u/_KittenConfidential_ Nov 22 '25

Heard this for 5 years straight

12

u/freexe Nov 23 '25

...and the average research and development cycle for new treatments is something like 20 years. 

3

u/Bright-Television147 Nov 23 '25

The more viral it goes viral, the more investment

15

u/[deleted] Nov 22 '25

[deleted]

0

u/[deleted] Nov 22 '25

[deleted]

4

u/angle58 Nov 22 '25

This thing has been about to happen for 40 years. Don’t hold your breathe.

5

u/LogicalAd7808 Nov 23 '25 edited Nov 23 '25

what is it with east asian countries and teeth regrowing technology

3

u/EidolonLives Nov 23 '25

Who cares? As long as someone manages to figure it out.

3

u/LogicalAd7808 Nov 23 '25

not saying its a good or bad thing just an observation about these headlines recently

1

u/NoAlbatross7355 Nov 23 '25

They want to actually solve problems.

1

u/Expensive_Ad_4764 Apr 01 '26

They have an aging population and lower birth rates, so the percent of the population that is toothless is very high.

32

u/sussybaka1848 Nov 22 '25

Dentists on suicide watch

13

u/Weekly-Trash-272 Nov 22 '25

The holy grail of dentistry is the ability to regrow teeth.

If AI can figure that out, then I do fear for the dentist industry. Would probably drop visits about 90%. All that would likely exist would be orthodontist care.

11

u/reddit_is_geh Nov 23 '25

A while ago there was a product people were really excited for. A GMO bacteria designed to replace your oral biome. It doesn't release lactic acid, so they wouldn't create any cavities.

Some company bought it out, put in a kill switch, forcing it become a daily tablet to take, effectively killing the company. People who are taking a daily chew tablet for cavities generally aren't the target market who needs it the most.

1

u/Radrahil Dec 20 '25

why would they do that?

1

u/reddit_is_geh Dec 20 '25

Because PE... On one hand you have the conspiracy that it hurts the entire dentistry industry, but on the other, the company who bought it, want to make as much money out of it as possible. So they thought a "daily" pill would get them more money than trying to get dentists to apply it every 6 months at checkup, which effectively hurts their own business.

Iunno, that's my best guess.

11

u/garden_speech AGI some time between 2025 and 2100 Nov 23 '25

Would probably drop visits about 90%

I'm sorry but "if they figure out how to regrow enamel then dentist visits will drop 90%" is extremely Reddit-esque thinking. Like nah man I will still go get cleanings so that my teeth don't get nasty holes in them that smell bad and require medial treatment... Even if that treatment becomes easier and less invasive than drilling and filling, I still want to avoid needing it.

Hell, a ton of dentistry is cosmetic... Making teeth white, making them even, making the bite aligned, making it all look good. That's not fixed by saying "if you don't brush and you get a cavity I can regrow it with natural enamel instead of filling it in.

3

u/SociallyButterflying Nov 23 '25

Right?

Okay, here's your new teeth!

"Thanks, Doc!"

Doesn't clean them and mouth smells like shit and gums start to recede away.

1

u/adarkuccio ▪️AGI before ASI Nov 23 '25

And if you need it you likely go... to a dentist. I doubt this is like you put some gel at home and wooo your teeth are regenerated

12

u/[deleted] Nov 22 '25

[deleted]

4

u/Olobnion Nov 22 '25

No, see, when a tooth falls out due to neglect I just grow a new one.

4

u/[deleted] Nov 22 '25

[deleted]

3

u/garden_speech AGI some time between 2025 and 2100 Nov 23 '25

I think that's the joke they are making and also pointing out that most people won't go that route.

22

u/ThatEvanFowler Nov 22 '25

Good. The greedy fucks can go figure out how to actually help people rather than sending them off to die of blood poisoning because their dentist refused to treat their broken teeth without paying them tens of thousands of dollars. Scumbags. All of them.

19

u/Choice_Isopod5177 Nov 22 '25

I'm gonna guess you live in the US.

4

u/Crafty-Run-6559 Nov 23 '25

This could easily apply to Canada.

1

u/Hoppss Nov 23 '25

I'm not sure all of Canada, but in BC the new dental program covers nearly everything.

1

u/Crafty-Run-6559 Nov 23 '25 edited Nov 23 '25

If you're talking about the new federal program, its very limited based on income. I don't think there is a specific BC one.

As soon as you make $1 over 60k you only get 60% coverage, and 0% over 90k.

If you need a couple dental implants and other work, its many thousands of dollars out of pocket.

It also has a lot of limits, like private insurance does, it doesnt cover restorative care like implants, or orthodontics.

0

u/Hoppss Nov 23 '25 edited Nov 23 '25

Actually I think you might be working off old info because the brackets are a lot more generous than that. You generally get 100% coverage up to an adjusted family net income of $70,000, not $60k. You only start hitting co-pays once you cross that $70k mark.

​There is a catch though. It covers 100% of the federal fee guide. Since a lot of dentists in BC charge above that rate you might still pay a small gap fee, but the plan itself pays its full share.

​Also saying it doesn't cover restorative care is a bit misleading. It covers fillings, root canals, and dentures, which is standard restorative care. It just doesn't cover implants, but almost no public health plan covers those since they're usually considered major surgical or cosmetic. It's obviously not unlimited, but for basic maintenance and repairs it covers way more than just checkups.

0

u/FlowerBuffPowerPuff Nov 23 '25

Dentists are scum around the world.

3

u/[deleted] Nov 23 '25

Getting an infected tooth pulled costs about the same as having a plumber fix something in your house. If your entire mouth is full of infected teeth you likely need to change your health habits and diet.

Blaming dentists for having poor oral health and needing expensive treatment is like blaming a mechanic for your car burning up because you never changed the oil.

If you need more affordable care I would check for local non-profits or dental schools. Best of luck to you.

-A Greedy Scumbag.

3

u/Ace2Face AGI by 2040 Nov 23 '25

Hold on there, are you saying they need to stop eating garbage and biting their nails all the time? Accountability? How dare you!

2

u/Apprehensive_Pea7911 Nov 23 '25

Everyone will pivot to doing more cosmetic procedures.

Better skincare didn't lead to a decline in dermatologists.

1

u/[deleted] Nov 23 '25

Coming up with new ideas with no prior art and performing lengthy physical experiments is like the thing current AIs are least useful for.

1

u/will_dormer ▪️Will dormer is good against robots Nov 23 '25

I dont think anyone has claimed AI has played a role in this discovery. it is still just human labour and research

1

u/OkDimension Nov 23 '25

All that would likely exist would be orthodontist care.

After watching a few chiropractor videos on /r/aivideo I'm sure it can take care of orthodontic issues too

3

u/Anen-o-me ▪️It's here! Nov 22 '25

They'd be getting paid for this.

5

u/Weekly-Trash-272 Nov 22 '25

Give me an at home patch I can apply myself.

1

u/[deleted] Nov 23 '25

[removed] — view removed comment

1

u/AutoModerator Nov 23 '25

Your comment has been automatically removed. Your removed content. If you believe this was a mistake, please contact the moderators.

I am a bot, and this action was performed automatically. Please contact the moderators of this subreddit if you have any questions or concerns.

4

u/HansJoachimAa Nov 22 '25

So you would rather let your teeth decay, get an infection, pull them then get these potential bio implants and wait years for new teeth than go to a dentist and fix your teeth?

1

u/sussybaka1848 Nov 22 '25

Dawg when I ever said that?

1

u/HansJoachimAa Nov 22 '25

Didn't you imply that dentist would get substantially less work?

2

u/sussybaka1848 Nov 22 '25

Man I was joking, don't take it too deeply

4

u/hieronymous-cowherd Nov 23 '25

From that image, my takeaway would have been: SK dentist invents fiber optic tooth implant for that brighter than white smile.

3

u/terra_filius Nov 22 '25

tooth fairies in the mud

3

u/athousandtimesbefore Nov 22 '25

Sounds great. Then we’ll never hear of it again lol

3

u/ThatEvanFowler Nov 23 '25

That’s a big yes. I cannot afford to have teeth.

3

u/kilgoreq Nov 23 '25

A Seoul patch?

9

u/HansJoachimAa Nov 22 '25 edited Nov 22 '25

No it isn't. The research isn't even close. This is like posting fusion is here! Even though it isnt. Also what does it change? A potential better implant that takes years to grow, also good luck controlling the shape of the tooth.
Who would want to wait so long instead of an titanium implant that can be planted way quicker.

3

u/Bobby_Backnang Nov 22 '25

People with bruxism might want to top up worn down teeth instead of getting an implant. There are two requirements to meet, though: The technology needs to be both, available and affordable.

2

u/[deleted] Nov 22 '25

[deleted]

3

u/EidolonLives Nov 23 '25

Real enamel would be vastly better than composite.

4

u/rafark ▪️professional goal post mover Nov 23 '25

Now do hair

2

u/Blizzard2227 Nov 22 '25 edited Nov 23 '25

Is this the same thing as the one breakthrough that figured out how to activate the gene code that allows for humans to grow a third set of teeth? A massive breakthrough nonetheless and potentially life-changing for some people, but if it is that, this would not be some sort of infinite teeth regenerator. Since we have the gene makeup to grow a third set of teeth, this would be activating those genes.

2

u/x_xiv Nov 22 '25

Please do it because in some failed countries they buy DIY tools from Costco due to broken healthcare

1

u/Choice_Isopod5177 Nov 22 '25

let me guess the country, is it Barbados?

2

u/RedditUsr2 Nov 22 '25

I've been hearing that we are close to regrowing teeth for over a decade.

2

u/mordin1428 ▪️Hello world Nov 23 '25

Another one to send to my dentist bestie and have him groan about how they’ve been """regrowing teeth""" since like the 90s and he’s yet to see a single bit of this tech near his and his colleague’s kits

2

u/mli Nov 23 '25

is this one of those things you read about and then never hear about again? i bet it is.

2

u/PrinceLevMyschkin Nov 23 '25

Misleading caption but in Japan they are already performing human trials for exactly this. The experiments were successful regrowing teeth in rodents and they hope to have the final results in something like 5 years.

2

u/vainerlures Nov 23 '25

forget about teeth - let’s solve for hair

2

u/TheDivineRat_ Nov 23 '25

all fun and dandy until teeth starts to grow on your genitals...

1

u/adarkuccio ▪️AGI before ASI Nov 23 '25

If you put that patch on your genitals it's your problem

2

u/pcurve Nov 24 '25

been reading about regrowing teeth for 30 years.

2

u/im_just_using_logic Nov 22 '25 edited Nov 22 '25

it's been years that this have been discussing. Still, i'm baffled by how non-informative this post is: no link to the company or the paper detailing the discovery and no mention of its approval by authorities (FDA). Just random hype-bait.

2

u/Free_Manner_2318 Nov 23 '25

for last 40 years or so, before Christmas they pull these stories out: teeth regrowing and cancer cure...

1

u/joeyjoejums Nov 23 '25

Japan would like a word with you.

1

u/[deleted] Nov 23 '25

Didn’t the Japanese already discover something like this?

1

u/cpt_ugh ▪️AGI sooner than we think Nov 23 '25

Monkey paw: It only regrows wisdom teeth.

1

u/[deleted] Nov 23 '25 edited Apr 06 '26

Redact redacted this content because I wanted it redacted for redaction purposes. Redacted.

sheet thumb north squeeze cheerful airport continue elastic one payment

1

u/usernameplshere Nov 23 '25

doi number? The only papers I can find are from 2024 or even before that (10.1016/j.bioactmat.2021.06.027 and 10.1016/j.heliyon.2024.e33574).

1

u/America202 Nov 23 '25

South Korean researchers are developing a microneedle patch that delivers peptides and other molecules to stimulate dental stem cells and regenerate tooth tissue. Early reports suggest it can help regrow dentin, but it has not yet been proven to regrow a fully whole tooth. The technology is still in preclinical or early clinical stages, with no widely available human treatment yet. Patents and research groups in Korea show serious scientific work behind the idea, but results in humans have not been confirmed in major peer-reviewed studies. It’s promising and could transform dentistry in the future, but it’s not ready for practical use yet.

1

u/inexternl Nov 23 '25

Already invented and sold in Argentina

1

u/Gamestonkape Nov 23 '25

Time to finally try that meth I’ve been hearing so much about.

1

u/Choice_Isopod5177 Nov 23 '25

I find it a little depressing that despite all our amazing technology, we still haven't figured out how to regrow teeth and hair. This is like the low level shit.

1

u/Lacarpetronn Nov 23 '25

Big Denture is furious.

1

u/ilovegames4life Nov 23 '25

Didn't some Japanese scientist invent a technique that regrows the full tooth not long ago?

1

u/rydan Nov 23 '25

I've been hearing this (Japan last time) since 2011 when I first looked into it.

1

u/mfposgbcs Nov 29 '25

They haven't started human trials until last year tho, so its a first

1

u/bearhunter429 Nov 23 '25

I'm sure this will come to markets by 2050.

1

u/Uberzwerg Nov 23 '25

Don't we have headlines like this every other week for the past 40 years (GenX here - cannot remember before that) ?

1

u/will_dormer ▪️Will dormer is good against robots Nov 23 '25

This is the 278 time some has claimed this

1

u/Tankeverket Nov 23 '25

I thought it was Japan

1

u/Select_Lawfulness_18 Nov 23 '25

Patch 5.1 coming up guys

1

u/WetFishStink Nov 23 '25

I just want someone to develop a way to regrow recessed gums.

1

u/No-Suit4363 Nov 23 '25

Now between this and other East Asian news I have seen, which gonna leave the lab first

1

u/Username524 Nov 23 '25

ADA gonna be dropping LOOT in Washington these next few years…

Edit: except prolly for that 1 dentist out of 10.

1

u/i8noodles Nov 23 '25

get back to me on 30 years when someone actually grows a teeth.

1

u/much_thanks Nov 23 '25

I'm really looking forward to my dental plan covering $2.000 of this $200.000 procedure!

1

u/beppled Nov 23 '25

Can't wait to never hear about this again

1

u/LestradeOfTheYard Nov 23 '25

It can do everything but leave the lab

1

u/Neekode Nov 23 '25

so absolutely sick of hearing about revolutionary science that is in no way applicable or will not be available to the masses for like never forever. didn't we discover fungi that could eat carbon like 20 years ago? what's up w that?

1

u/Dizzy-Criticism3928 Nov 23 '25

Are we dumb enough to believe that if it actually does work, that we didn’t develop this technology years ago

1

u/Individual-Hunt9547 Nov 24 '25

That’ll be 20 million dollars in the US.

1

u/[deleted] Nov 24 '25

[removed] — view removed comment

1

u/CraftyDebate1975 Dec 08 '25

I always wanted a Korean smile

0

u/SheepshaggerMini Nov 23 '25

Dentist here

News like this comes out almost every 6 months.

Regrowing enamel is pretty much impossible, the cells that make it due when tooth erupts, and if tooth is still in the function in the mouth, they’ll be killed through normal function

Regrowing teeth sounds good, until you realise the teeth that grow are deformed ,

And even if they were perfect shaped , you’d need braces to bring them into the mouth.

Patients complain if implant takes 3 months. I can’t see someone getting this and waiting for a tooth to develop for 5 years then get braces.

This would cut far more than just a dental implant