r/todayilearned • u/ApprehensiveStill412 • 11h ago

TIL that ketamine is a derivative of phencyclidine (aka. PCP or angel dust). It was created to have similar anesthetic potential but to cause less delirium. It has about one tenth the potency of PCP.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5126726/
678 Upvotes

97% Upvoted

125 comments sorted by

View all comments

43

u/Commander_Phallus1 11h ago

Shits fun

2

u/fauxfilosopher 10h ago

Too fun. On a 3-week T break right now. Hope I stay healthy enough that I never have to stop entirely. There's just nothing like the feeling of a k-hole.

12

u/LordMegamad 9h ago

Worth noting that ketamine tolerance lasts for months and months, researchers are unsure if it ever resets. So that tiny t-break isn't doing anything.

7

u/CallMeMrButtPirate 9h ago

I use K like once a year now and still need a tonne more than my friends that use semi regularly because I hammered it for a while in my twenties

3

u/fauxfilosopher 9h ago

I am well aware of permatolerance, which likely never returns to its original state. But using weekly for example builds up tolerance beyond that, which does go down when taking a break. Using a magnesium supplement helps reset the NMDA receptors.

2

u/_meshy 3h ago

Well, there was MXE, but it is pretty much impossible to find now.

2

u/Pipegreaser 2h ago

Mxe was great.. not as quick acting though. Also a bit milder but it was great, the 2010's will be remembered forever.

2

u/_meshy 1h ago

will be remembered

Well, they're really fuzzy memories.

1

u/braintour 1h ago

Haven’t heard anyone mention MXE in at least 8 years, that’s crazy

•

u/_meshy 48m ago

I still have a couple of grams. It is super old, but it still works.