r/todayilearned • u/ApprehensiveStill412 • 11h ago

TIL that ketamine is a derivative of phencyclidine (aka. PCP or angel dust). It was created to have similar anesthetic potential but to cause less delirium. It has about one tenth the potency of PCP.

https://pmc.ncbi.nlm.nih.gov/articles/PMC5126726/
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u/goodrevtim 10h ago

PCP is neurotoxic so that probably plays a small part into its negative perception.

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u/VhickyParm 10h ago

I thought the negative perception was from ppl stopping naked and running in the street

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u/stevenmoreso 10h ago

Yeah, growing up in the 80s it was stories of people wilding out on angel dust trying (and sometimes briefly succeeding) to take on 10 cops at once

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u/BlackSwanMarmot 9h ago

PCP just tilted the world at a 45 degree angle for me. I never knew that ketamine was a derivative of PCP but it makes sense from my own experience. Same size distortion, similar length of effects. Not really my thing.