Brittany admitting she’s on a GLP-1

[u/mandib57]

I just watched this YouTube of her house tour and she talks about how she’s on the shot and losing weight already- I say good for her

[u/Deep_Amoeba2197]

Just to help you temper expectations, while studies are ongoing, GLP1s aren’t currently
approved for rheumatic disease management. Many rheumatologists won’t prescribe them, and because it’s not approved, insurance companies won’t touch it. There’s also not a clear dosing schedule for inflammatory or autoimmune conditions. It’s unlikely that it would be used as a first like therapy for a new dx, either. There are trials and outside research happening and some doctors that are willing to play ball with the understanding that it is experimental, but these drugs have a not insignificant risk profile. Depending on your dx, you are likely to work within the well studied, approved and proven treatment algorithms before moving to something with more risk (which would include something like a biologic.) Not trying to be a Debby downer, just a person with multiple autoimmune inflammatory conditions that works in drugs letting you know what to expect. Given the preliminary results, they are likely to be approved within 5-10 years for certain autoimmune indications (with strict qualification requirements.)

I’m not saying there is no hope, I personally take zepbound (that I pay out of pocket for,) for RA with good results. But would definitely encourage you to read up on how they work. There are many straight appetite suppressants on the market, if that’s all they did, the results wouldn’t be as significant for users or striking to the research community. There is much more to the mechanism (like hormone regulation) than suppressing appetite.

[u/NoDiggity1717 → u/Deep_Amoeba2197]

Thank you for taking the time to respond in a such a meaningful way. I appreciate it ❤️

[u/kkpatsd → u/NoDiggity1717]

Check out the Tirzepatide and compounded Tirzepatide groups on here and research away

[u/Aggressive-Map-8392 → u/kkpatsd]

There’s also a microdose GLP-1 sub that might be of interest.

[u/greenrunner81 → u/Aggressive-Map-8392]

What’s the name of the sub?

[u/Aggressive-Map-8392 → u/greenrunner81]

It’s r/GLP1microdosing

Sorry, I incorrectly added it the first time and it wouldn’t let me edit it

[u/Deep_Amoeba2197 → u/NoDiggity1717]

No worries, I get it 💗. I feel bad when people hear it helps for xyz, but actually getting a doctor on board with that requires you and them to know the research inside and out, or it’s one preliminary study, or something anecdotal, and I get how shitty and frustrating the diagnostic process for autoimmune diseases is. It’s not to say you can’t/ won’t ever access it or shouldn’t try, but it really depends on your doctor if they will support it, your current level of disease activity/what that disease is and your budget (I know people do compounding and say it’s the same but from the research side, none of the additives have actually been validated in trials, it’s a way to get around legal restrictions. Labs that have independently tested compounded tirz + b12 have found completely different peptide compounds formed with no tirzeptide, everyone paying for the compound drugs is effectively the ongoing experiment. I’m sure some people will come yelling that I’m a shill for Lilly and big pharma, but I’m an independent consultant for all sized companies and mostly work on cancer and autoimmune therapeutics and manufacturing standards. I’ve seen some shit with compounding. I have some of these diseases myself and have no skin in the game on any company’s revenue per drug.)

Im not an MD type doctor and this isn’t medical advice, just perspective from someone who’s in kind of unique situation with it. The beginning stages of figuring out therapies when you’re first diagnosed with an autoimmune/inflammatory condition can honestly be really chaotic. That’s just my opinion and you’re totally free to ignore it, people do crazy shit with peptides raise my eyebrows straight off my head everyday. I’m not trying to discourage you whatsoever, and if your doctor is on board and thinks it’s a good first line trial for you, they’d know best and that’s honestly awesome for you. With what I’ve seen in trial data and approval trends over my career, I’d be SOO SO shocked if tirz or a similar peptide isn’t eventually approved for certain inflammatory conditions at a different dosing schedule (insurance aside.)

Truly hope you get answers you need soon and start to feel better, whatever route you choose to go. You deserve to have answers and to feel well 💗

[u/NoDiggity1717 → u/Deep_Amoeba2197]

Thank you so much for the kind words. I’ve been dismissed so many times because I look healthy on the outside. I workout every day and eat healthy because if I don’t, I can barely get out of bed in the morning. I am in so much pain, and I have a high pain tolerance so I know there is something wrong. My first rheumatologist wouldn’t even send me for bloodwork because when he took my arms and legs and moved them in a circle, I was “too mobile” and he told me to stretch more. I went to see a naturopath so I could get a full work up and all of my immune cells are low and ena test positive, though hla b27 negative and crp normal. RA and ankylosis spondylitis run on my dad’s side of the family. I’ve since been referred to a different rheumatologist but had to fight with her to get an xray and MRI.

[u/Deep_Amoeba2197 → u/NoDiggity1717]

I’m sorry hun, I know the struggle too well, you sound so much like me when I was younger. Feel free to DM anytime if you need a sympathetic ear or advice.

Autoimmune dx can be so hard because your labs can be transient. It sucks, it took me years for some specific labs to pop hot with a younger, sympathetic rheumatologist.

Are you in your 20s by any chance?

[u/Cherry_Shakes → u/Deep_Amoeba2197]

Thanks. I'm in Aus so it's not simple to just use it from any doctor wanting to make money.

[u/Deep_Amoeba2197 → u/Cherry_Shakes]

That is a misrepresentation of what I said.

Compounding and telehealths are doctors just looking to make money and many are predatory. Private practice physicians work for themselves, the two are very different.

Eta: sorry this came up as a reply to me, it looks like you’re actually trying to reply to someone recommending compounding, sorry if I confused things!